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Tindamax Generic Name & Formulations
Legal Class
Rx
General Description
Tinidazole 500mg; scored tabs.
Pharmacological Class
Nitroimidazole.
How Supplied
Tabs—20
Manufacturer
Generic Availability
YES
Tindamax Indications
Indications
Giardiasis. Intestinal amebiasis. Amebic liver abscess.
Tindamax Dosage and Administration
Adult
Take with food. Giardiasis: 2g as a single dose. Intestinal amebiasis: 2g once daily for 3 days. Amebic liver abscess: 2g once daily for 3–5 days. Hemodialysis: if dose given on or prior to a dialysis day, supplement with ½ the recommended dose after session.
Children
<3yrs: not established. Take with food. ≥3yrs: Giardiasis: 50mg/kg (max 2g) as a single dose. Intestinal amebiasis: 50mg/kg/day (max 2g) for 3 days. Amebic liver abscess: 50mg/kg/day (max 2g) for 3–5 days.
Tindamax Contraindications
Contraindications
Previous hypersensitivity to other nitroimidazole derivatives. Cockayne syndrome.
Tindamax Boxed Warnings
Boxed Warning
Potential risk for carcinogenicity.
Tindamax Warnings/Precautions
Warnings/Precautions
Potential risk for genotoxicity and carcinogenicity; avoid chronic use. Discontinue if neurological effects occur. Vaginal candidiasis. Blood dyscrasias. Monitor leukocytes if re-treatment needed. Hepatic dysfunction. Elderly. Pregnancy. Nursing mothers: not recommended (during and for 72hrs after last dose).
Tindamax Pharmacokinetics
See Literature
Tindamax Interactions
Interactions
Avoid alcohol during and for 3 days after therapy. Do not give within 2 weeks of disulfiram. May potentiate oral anticoagulants, lithium, phenytoin. Monitor cyclosporine, tacrolimus, fluorouracil. May be antagonized by CYP3A4 inducers (eg, phenobarbital, rifampin). May be potentiated by CYP3A4 inhibitors (eg, cimetidine, ketoconazole). Separate dosing of cholestyramine. May interfere with serum chemistry tests (eg, AST, ALT, LDH, triglycerides, hexokinase glucose).
Tindamax Adverse Reactions
Adverse Reactions
Metallic/bitter taste, nausea, weakness/fatigue/malaise, dyspepsia/cramps/epigastric discomfort, vomiting, anorexia, constipation, dizziness, headache, transient leukopenia/neutropenia; seizures, peripheral neuropathy.
Tindamax Clinical Trials
See Literature
Tindamax Note
Not Applicable
Tindamax Patient Counseling
See Literature
Tindamax Generic Name & Formulations
Legal Class
Rx
General Description
Tinidazole 500mg; scored tabs.
Pharmacological Class
Nitroimidazole.
How Supplied
Tabs—20
Manufacturer
Generic Availability
YES
Tindamax Indications
Indications
Trichomoniasis. Bacterial vaginosis in non-pregnant women.
Tindamax Dosage and Administration
Adult
Take with food. Trichomoniasis: 2g as a single dose; treat consorts also. Bacterial vaginosis: 2g once daily for 2 days or 1g once daily for 5 days. Hemodialysis: if dose given on or prior to a dialysis day, supplement with ½ the recommended dose after session.
Children
Not established.
Tindamax Contraindications
Contraindications
Previous hypersensitivity to other nitroimidazole derivatives. Cockayne syndrome.
Tindamax Boxed Warnings
Boxed Warning
Potential risk for carcinogenicity.
Tindamax Warnings/Precautions
Warnings/Precautions
Potential risk for genotoxicity and carcinogenicity; avoid chronic use. Discontinue if neurological effects occur. Vaginal candidiasis. Blood dyscrasias. Monitor leukocytes if re-treatment needed. Hepatic dysfunction. Elderly. Pregnancy. Nursing mothers: not recommended (during and for 72hrs after last dose).
Tindamax Pharmacokinetics
See Literature
Tindamax Interactions
Interactions
Avoid alcohol during and for 3 days after therapy. Do not give within 2 weeks of disulfiram. May potentiate oral anticoagulants, lithium, phenytoin. Monitor cyclosporine, tacrolimus, fluorouracil. May be antagonized by CYP3A4 inducers (eg, phenobarbital, rifampin). May be potentiated by CYP3A4 inhibitors (eg, cimetidine, ketoconazole). Separate dosing of cholestyramine. May interfere with serum chemistry tests (eg, AST, ALT, LDH, triglycerides, hexokinase glucose).
Tindamax Adverse Reactions
Adverse Reactions
Metallic/bitter taste, nausea, weakness/fatigue/malaise, dyspepsia/cramps/epigastric discomfort, vomiting, anorexia, constipation, dizziness, headache, transient leukopenia/neutropenia; seizures, peripheral neuropathy.
Tindamax Clinical Trials
See Literature
Tindamax Note
Not Applicable
Tindamax Patient Counseling
See Literature
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