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Tazicef Generic Name & Formulations
Legal Class
Rx
General Description
Ceftazidime 1g, 2g; pwd for IM or IV inj, or IV infusion after reconstitution; sodium content 2.3mEq/g.
Pharmacological Class
Cephalosporin.
How Supplied
Vials 1g—1, 10, 25
2g—1, 10
2g—1, 10
Manufacturer
Tazicef Indications
Indications
Susceptible infections including lower respiratory tract (eg, pneumonia), skin and skin structure, UTIs, septicemia, bone and joint, gynecologic (eg, endometritis, pelvic cellulitis), meningitis, intraabdominal (eg, peritonitis).
Tazicef Dosage and Administration
Adult
Administer in upper outer quadrant of the gluteus maximus or lateral part of the thigh. Usual dose: 1g IV or IM every 8–12 hours. Uncomplicated UTIs: 250mg IV or IM every 12 hours. Complicated UTIs: 500mg IV or IM every 8–12 hours. Bone and joint: 2g IV every 12 hours. Uncomplicated pneumonia, mild skin and skin structure: 500mg–1g IV or IM every 8 hours. Serious gynecologic, intraabdominal, meningitis, or very severe life threatening (eg, immunocompromised): 2g IV every 8 hours. Lung infections: 30–50mg/kg IV every 8 hours; max of 6g/day. Renal dysfunction: CrCl 31–50mL/min: 1g every 12 hours; CrCl 16–30mL/min: 1g every 24 hours; CrCl 6–15mL/min: 500mg every 24 hours; CrCl <5mL/min: 500mg every 48 hours. Hemodialysis: 1g loading dose then 1g after each dialysis session. Peritoneal dialysis: 1g loading dose then 500mg every 24 hours.
Children
Neonates: 30mg/kg IV every 12 hours. 1 month-12 years: 30–50mg/kg IV every 8 hours, max of 6g/day. Renal impairment: reduce dose.
Tazicef Contraindications
Not Applicable
Tazicef Boxed Warnings
Not Applicable
Tazicef Warnings/Precautions
Warnings/Precautions
Penicillin or other allergy. Renal or hepatic impairment, poor nutritional state, long term use: monitor prothrombin time. GI disease (esp. colitis). Pregnancy (Cat.B). Nursing mothers.
Tazicef Pharmacokinetics
See Literature
Tazicef Interactions
Interactions
Nephrotoxicity with concomitant aminoglycosides, diuretics (eg, furosemide). Antagonized by chloramphenicol. False (+) glucose test with Clinitest, Benedict's, or Fehling's soln.
Tazicef Adverse Reactions
Adverse Reactions
Hypersensitivity reactions (eg, rash, pruritus, fever), local reactions, GI upset, elevated liver enzymes.
Tazicef Clinical Trials
See Literature
Tazicef Note
Not Applicable
Tazicef Patient Counseling
See Literature
