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Tamiflu Generic Name & Formulations
Legal Class
Rx
General Description
Oseltamivir (as phosphate) 30mg, 45mg, 75mg; caps.
Pharmacological Class
Neuraminidase inhibitor.
See Also
How Supplied
Caps—10; Susp—60mL
Manufacturer
Generic Availability
NO
Tamiflu Indications
Indications
Treatment of uncomplicated acute illness due to influenza infection in patients ≥2 weeks of age who have been symptomatic for ≤48hrs. Prophylaxis of influenza in patients ≥1yr of age.
Limitations of Use
Not a substitute for annual influenza vaccination. Consider available information on influenza drug susceptibility patterns and treatment effects when deciding whether to use. Not recommended for patients with ESRD not undergoing dialysis.
Tamiflu Dosage and Administration
Adult
Start within 2 days of symptom onset or exposure. Unable to swallow caps; use oral susp. If oral susp. unavailable; may open caps and mix with sweetened liquids (eg, chocolate syrup, corn syrup, caramel topping, or light brown sugar (dissolved in water). If appropriate strength caps and oral susp. unavailable; have RPh compound an emergency supply of oral susp. from 75mg caps (see full labeling for preparation). ≥13yrs: Treatment: 75mg twice daily for 5 days. Prophylaxis: after close contact with infected individual: 75mg once daily for at least 10 days; during community outbreak: 75mg once daily for up to 6 weeks (or up to 12 weeks in immunocompromised). Renal impairment or ESRD on dialysis: see full labeling.
Children
Start within 2 days of symptom onset or exposure. Unable to swallow caps; use oral susp. If oral susp. unavailable; may open caps and mix with sweetened liquids (eg, chocolate syrup, corn syrup, caramel topping, or light brown sugar (dissolved in water). If appropriate strength caps and oral susp. unavailable; have RPh compound an emergency supply of oral susp. from 75mg caps (see full labeling for preparation). Treatment: <2 weeks: not established. Treat for 5 days. ≥2 weeks to <1yr: 3mg/kg twice daily. 1–12yrs: (≤15kg): 30mg twice daily; (15.1–23kg): 45mg twice daily; (23.1–40kg): 60mg twice daily; (≥40.1kg): 75mg twice daily. Prophylaxis: <1yr: not established. Treat for 10 days; during community outbreak: continue up to 6 weeks (or up to 12 weeks in immunocompromised); 1–12yrs: (≤15kg): 30mg once daily; (15.1–23kg): 45mg once daily; (23.1–40kg): 60mg once daily; (≥40.1kg): 75mg once daily.
Tamiflu Contraindications
Not Applicable
Tamiflu Boxed Warnings
Not Applicable
Tamiflu Warnings/Precautions
Warnings/Precautions
Immunocompromised. Monitor for signs of abnormal behavior. Risk of bacterial infections. Chronic cardiac or respiratory disease. Severe hepatic impairment. Oral soln: hereditary fructose intolerance. Pregnancy. Nursing mothers.
Tamiflu Pharmacokinetics
See Literature
Tamiflu Interactions
Interactions
Do not administer live attenuated influenza vaccine within 2 weeks prior or 48hrs after treatment.
Tamiflu Adverse Reactions
Adverse Reactions
Nausea, vomiting, headache, pain; also Children <1yr: diarrhea, diaper rash; serious skin/hypersensitivity reactions (discontinue if occur), possible neuropsychiatric events (eg, hallucinations, delirium, abnormal behavior).
Tamiflu Clinical Trials
See Literature
Tamiflu Note
Not Applicable
Tamiflu Patient Counseling
See Literature
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