Suprax

— THERAPEUTIC CATEGORIES —
  • Bacterial infections
PAGE CONTENTS
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  • Generic Name & Formulations
  • Indications
  • Dosage and Administration
  • Contraindications
  • Boxed Warnings
  • Warnings/Precautions
  • Pharmacokinetics
  • Interactions
  • Adverse Reactions
  • Clinical Trials
  • Note
  • Patient Counseling

    • Suprax Generic Name & Formulations

    Legal Class

    Rx

    General Description

    Cefixime 400mg; caps.

    Pharmacological Class

    Cephalosporin.

    See Also

    How Supplied

    Caps—50; Chew tabs—10, 50; Susp 100mg/5mL—50mL, 75mL, 100mL; 200mg/5mL—25mL, 37.5mL, 50mL, 75mL, 100mL; 500mg/5mL—10mL, 20mL

    Manufacturer

    Lupin Pharmaceuticals, Inc.

    Generic Availability

    NO

    Mechanism of Action

    Bactericidal action of cefixime results from inhibition of cell-wall synthesis.

    Suprax Indications

    Indications

    Susceptible infections, including pharyngitis, tonsillitis, acute exacerbation of chronic bronchitis; uncomplicated UTIs and cervical or urethral gonorrhea.

    Suprax Dosage and Administration

    Adult

    400mg once daily or 200mg every 12 hrs. Gonorrhea: 400mg once. Infections due to Streptococcus pyogenes: treat for at least 10 days. Renal impairment: adjust dose; see full labeling.

    Children

    <6 months: not established. Chew tabs: chew or crush before swallowing. <50kg and 6 months–12yrs: 8mg/kg once daily or 4mg/kg every 12 hrs. >50kg or >12yrs: use adult dose. Otitis media: treat with chew tabs or susp; do not substitute with tabs. Infections due to Streptococcus pyogenes: treat for at least 10 days.

    Administration

    Capsules may be administered without regard to food. Chewable tablets must be chewed or crushed before swallowing. Capsules should not be substituted for the chewable tablets or suspension in the treatment of otitis media. For oral suspension: follow reconstitution instructions; shake well before using. Discard unused portion after 14 days.

    Nursing Considerations

    Capsules may be administered without regard to food. Chewable tablets must be chewed or crushed before swallowing. Capsules should not be substituted for the chewable tablets or suspension in the treatment of otitis media. For oral suspension: follow reconstitution instructions; shake well before using. Discard unused portion after 14 days.

    Suprax Contraindications

    Not Applicable

    Suprax Boxed Warnings

    Not Applicable

    Suprax Warnings/Precautions

    Warnings/Precautions

    Penicillin or other allergy. Evaluate if diarrhea occurs. Renal impairment. History of GI disease. Poor nutritional state. Chew tabs: phenylketonuria. Pregnancy. Nursing mothers.

    Suprax Pharmacokinetics

    Elimination

    Renal.

    Suprax Interactions

    Interactions

    May potentiate carbamazepine, anticoagulants (eg, warfarin); monitor. May cause false (+) Clinitest, direct Coomb's, nitroprusside test for ketones. Potentiated by probenecid.

    Suprax Adverse Reactions

    Adverse Reactions

    Diarrhea, nausea, loose stools, abdominal pain, dyspepsia, vomiting, hypersensitivity reactions, headache, dizziness, seizures, transient renal and hepatic effects; C. difficile-associated diarrhea.

    Suprax Clinical Trials

    See Literature

    Suprax Note

    Not Applicable

    Suprax Patient Counseling

    See Literature

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