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Sulfadiazine Generic Name & Formulations
Legal Class
Rx
General Description
Sulfadiazine 500mg; tabs.
Pharmacological Class
Sulfonamide antibiotic.
How Supplied
Tabs—100, 1000
Manufacturer
Sulfadiazine Indications
Indications
Susceptible infections including chancroid, trachoma, inclusion conjunctivitis, nocardiosis, UTI (secondary therapy), toxoplasmosis encephalitis, meningococcal meningitis, acute otitis media, rheumatic fever.
Sulfadiazine Dosage and Administration
Adult
Initially 2–4g. Maintenance: 2–4g divided into 3–6 doses every 24 hours.
Children
<2 months: see Contraindications. ≥2months: Initially ½ the 24-hour dose. Maintenance: 150mg/kg divided into 4–6 doses every 24 hours, max 6g/24hrs. Rheumatic fever prophylaxis: <30kg: 500mg every 24 hours; >30kg: 1g every 24 hours.
Sulfadiazine Contraindications
Contraindications
Infants <2 months of age (except as adjunctive therapy with pyrimethamine in the treatment of congenital toxoplasmosis). Pregnancy at term. Nursing mothers.
Sulfadiazine Boxed Warnings
Not Applicable
Sulfadiazine Warnings/Precautions
Warnings/Precautions
Do not use to treat group A betahemolytic streptococcal infections. Renal or hepatic impairment. Bronchial asthma. Severe allergy. G6PD deficiency. Maintain adequate hydration. Obtain CBCs and urinalyses frequently during therapy. Pregnancy (Cat.C).
Sulfadiazine Pharmacokinetics
See Literature
Sulfadiazine Interactions
Interactions
May be potentiated by indomethacin, probenecid, salicylates. May potentiate oral anticoagulants, methotrexate, sulfonylureas, thiazide diuretics, uricosuric agents.
Sulfadiazine Adverse Reactions
Adverse Reactions
Blood dyscrasias, allergic reactions, GI upset, hepatitis, pancreatitis, stomatitis, headache, peripheral neuritis, depression, convulsions, ataxia, hallucinations, tinnitus, vertigo, insomnia, crystalluria, stone formation, toxic nephrosis, oliguria, anuria; rare: goiter production, diuresis, hypoglycemia.
Sulfadiazine Clinical Trials
See Literature
Sulfadiazine Note
Not Applicable
Sulfadiazine Patient Counseling
See Literature
