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Streptomycin Inj Generic Name & Formulations
Legal Class
Rx
General Description
Streptomycin sulfate 1g/vial; lyophilized pwd for IM inj after reconstitution.
Pharmacological Class
Aminoglycoside.
How Supplied
Contact supplier.
Manufacturer
Streptomycin Inj Indications
Indications
Moderate to severe susceptible infections, including plague, tularemia, endocarditis. Second-line therapy for gram-negative bacillary bacteremia, meningitis, pneumonia, brucellosis, granuloma inguinale, chancroid, UTIs.
Streptomycin Inj Dosage and Administration
Adult
Give by IM inj into gluteus maximus or mid-lateral thigh. Alternate injection sites. Tularemia: 1–2g per day in divided doses; give for 7–14 days until patient is afebrile for 5–7 days. Plague: 2g per day in 2 divided doses; give for at least 10 days. Streptococcal endocarditis: 1g twice daily for 1st week, then 500mg twice daily for for 2nd week; may be used with penicillin. >60years: 500mg twice daily for entire 2-weeks. Enterococcal endocarditis: 1g twice daily for 2 weeks, then 500mg twice daily for additional 4 weeks; given with penicillin. Other moderate to severe infections as 2nd-line therapy: 1–2g in divided doses every 6–12hrs; max 2g/day.
Children
Give by IM inj into mid-lateral thigh. Alternate injection sites. Tularemia, plague, endocarditis: See literature. Other moderate to severe infections as 2nd-line therapy: 20–40mg/kg per day in divided doses every 6–12hrs.
Streptomycin Inj Contraindications
Not Applicable
Streptomycin Inj Boxed Warnings
Not Applicable
Streptomycin Inj Warnings/Precautions
Warnings/Precautions
Renal impairment: reduce dose, monitor renal function and peak serum levels (max 20–25micrograms/mL) periodically. Perform baseline and periodic caloric stimulation, and audiometric tests with extended therapy. Discontinue if ototoxicity occurs. Venereal infections: if concomitant syphilis suspected, perform dark field examination before starting therapy then monthly serologic tests for at least 4 months. Elderly. Infants. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
Streptomycin Inj Pharmacokinetics
See Literature
Streptomycin Inj Interactions
Interactions
Avoid concurrent or sequential use of polymyxin B, colistin, cyclosporine, other aminoglycosides, neurotoxic or nephrotoxic drugs. Ototoxicity potentiated with ethacrynic acid, furosemide, mannitol, other diuretics. May potentiate neuromuscular blockade and respiratory paralysis with anesthetics, muscle relaxants.
Streptomycin Inj Adverse Reactions
Adverse Reactions
Ototoxicity (eg, cochlear and vestibular), paresthesias, rash, fever, urticaria, angioneurotic edema, eosinophilia, dermatitis, anaphylaxis, azotemia, blood dyscrasias, hemolytic anemia, muscle weakness, amblyopia; rare: nephrotoxicity.
Streptomycin Inj Clinical Trials
See Literature
Streptomycin Inj Note
Not Applicable
Streptomycin Inj Patient Counseling
See Literature
Streptomycin Inj Generic Name & Formulations
Legal Class
Rx
General Description
Streptomycin sulfate 1g/vial; lyophilized pwd for IM inj after reconstitution.
Pharmacological Class
Aminoglycoside.
How Supplied
Contact supplier.
Manufacturer
Streptomycin Inj Indications
Indications
Adjunct in tuberculosis.
Streptomycin Inj Dosage and Administration
Adult
Give by IM inj into gluteus maximus or mid-lateral thigh. Alternate injection sites. 15mg/kg (max 1g) once daily, or 25–30mg/kg (max 1.5g) two or three times weekly. Max 120g over entire course of therapy. Treat at least 1 year. >60years: reduce dose.
Children
Give by IM inj into mid-lateral thigh. Alternate injection sites. 20–40mg/kg (max 1g) once daily, or 25–30mg/kg (max 1.5g) two or three times weekly. Max 120g over entire course of therapy. Treat at least 1 year.
Streptomycin Inj Contraindications
Not Applicable
Streptomycin Inj Boxed Warnings
Not Applicable
Streptomycin Inj Warnings/Precautions
Warnings/Precautions
Renal impairment: reduce dose, monitor renal function and peak serum levels (max 20–25micrograms/mL) periodically. Perform baseline and periodic caloric stimulation, and audiometric tests with extended therapy. Discontinue if ototoxicity occurs. Elderly. Infants. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
Streptomycin Inj Pharmacokinetics
See Literature
Streptomycin Inj Interactions
Interactions
Avoid concurrent or sequential use of polymyxin B, colistin, cyclosporine, other aminoglycosides, neurotoxic or nephrotoxic drugs. Ototoxicity potentiated with ethacrynic acid, furosemide, mannitol, other diuretics. May potentiate neuromuscular blockade and respiratory paralysis with anesthetics, muscle relaxants.
Streptomycin Inj Adverse Reactions
Adverse Reactions
Ototoxicity (eg, cochlear and vestibular), paresthesias, rash, fever, urticaria, angioneurotic edema, eosinophilia, dermatitis, anaphylaxis, azotemia, blood dyscrasias, hemolytic anemia, muscle weakness, amblyopia; rare: nephrotoxicity.
Streptomycin Inj Clinical Trials
See Literature
Streptomycin Inj Note
Not Applicable
Streptomycin Inj Patient Counseling
See Literature
