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Stavudine Generic Name & Formulations
Legal Class
Rx
General Description
Stavudine 15mg, 20mg, 30mg, 40mg; caps.
Pharmacological Class
Nucleoside analogue (reverse transcriptase inhibitor).
How Supplied
Contact supplier
Manufacturer
Stavudine Indications
Indications
HIV-1 infection.
Stavudine Dosage and Administration
Adult
≥60kg: 40mg every 12hrs; <60kg: 30mg every 12hrs. Renal impairment: ≥60kg (CrCl 26–50mL/min): 20mg every 12hrs; (CrCl 10–25mL/min): 20mg every 24hrs. <60kg (CrCl 26–50mL/min): 15mg every 12hrs; (CrCl 10–25mL/min): 15mg every 24hrs. Hemodialysis: ≥60kg: 20mg every 24hrs; <60kg: 15mg every 24hrs. Coincide dose for end of dialysis and give at same time of day on non-dialysis days.
Children
≤13 days: 0.5mg/kg every 12hrs. ≥14 days: (<30kg): 1mg/kg every 12hrs; (≥30kg): use adult dose. Renal impairment: insufficient data.
Stavudine Contraindications
Contraindications
Concomitant didanosine.
Stavudine Boxed Warnings
Boxed Warning
Lactic acidosis and hepatomegaly with steatosis. Pancreatitis.
Stavudine Warnings/Precautions
Warnings/Precautions
Suspend if lactic acidosis or hepatotoxicity (eg, hepatomegaly and steatosis) occurs. Women, obesity, or prolonged nucleoside exposure: increased risk of toxicity. Pre-existing liver dysfunction, hepatitis, or other risk factors of liver disease; monitor. Increased risk of peripheral neuropathy in advanced HIV disease, history of peripheral neuropathy, or when concomitant neurotoxic drugs; monitor and consider permanent discontinuation if develops. Suspend if pancreatitis is suspected; if confirmed may restart with caution and monitor closely. Monitor for signs/symptoms of lipoatrophy. Renal impairment. Elderly. Pregnancy. Nursing mothers: not recommended.
Stavudine Pharmacokinetics
See Literature
Stavudine Interactions
Interactions
Avoid concomitant zidovudine. Increased risk of pancreatitis, hepatotoxicity, severe peripheral neuropathy with hydroxyurea; avoid. Caution with doxorubicin, ribavirin. Monitor for treatment-associated toxicities with interferon-alpha with or without ribavirin.
Stavudine Adverse Reactions
Adverse Reactions
Headache, diarrhea, nausea, vomiting, peripheral neurologic symptoms, rash, elevated liver enzymes, elevated amylase; pancreatitis, lactic acidosis or severe hepatomegaly with steatosis, lipoatrophy, immune reconstitution syndrome.
Stavudine Clinical Trials
See Literature
Stavudine Note
Notes
Formerly known under the brand name Zerit. Register pregnant patients exposed to stavudine by calling (800) 258-4263.
Stavudine Patient Counseling
See Literature
