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Sivextro Injection Generic Name & Formulations
Legal Class
Rx
General Description
Tedizolid phosphate 200mg; lyophilized pwd for IV infusion after reconstitution; preservative-free.
Pharmacological Class
Oxazolidinone.
See Also
How Supplied
Tabs—6 (blister pack), 30; Single-dose vials—10
Manufacturer
Generic Availability
NO
Sivextro Injection Indications
Indications
Susceptible acute bacterial skin and skin structure infections (ABSSSI).
Sivextro Injection Dosage and Administration
Adults and Children
<12yrs: not established. Give by IV over 1 hour. ≥12yrs: 200mg once daily for 6 days. Switching from IV to oral: no dose adjustment necessary.
Sivextro Injection Contraindications
Not Applicable
Sivextro Injection Boxed Warnings
Not Applicable
Sivextro Injection Warnings/Precautions
Warnings/Precautions
Not adequately evaluated in patients with neutropenia (ANC <1000 cells/mm3); consider alternate therapies. Risk of C. difficile-associated diarrhea; discontinue if suspected or confirmed. Pregnancy. Nursing mothers.
Sivextro Injection Pharmacokinetics
See Literature
Sivextro Injection Interactions
Interactions
Tabs: May potentiate oral BCRP substrates; consider interrupting co-administered substrates esp. those with narrow therapeutic index (eg, methotrexate, topotecan); monitor if coadministration (including rosuvastatin) is necessary.
Sivextro Injection Adverse Reactions
Adverse Reactions
Nausea, headache, diarrhea, infusion- or inj site reactions, vomiting, dizziness. In children: phlebitis, increased hepatic transaminases.
Sivextro Injection Clinical Trials
See Literature
Sivextro Injection Note
Not Applicable
Sivextro Injection Patient Counseling
See Literature
