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Seromycin Generic Name & Formulations
Legal Class
Rx
General Description
Cycloserine 250mg; caps.
Pharmacological Class
Antibacterial.
How Supplied
Caps—40
Manufacturer
Seromycin Indications
Indications
In conjunction with other chemotherapy, for the treatment of active pulmonary and extrapulmonary tuberculosis (including renal disease) when the causative organisms are susceptible and when treatment with primary drugs (streptomycin, isoniazid, rifampin, ethambutol) has proved inadequate.
Seromycin Dosage and Administration
Adult
Initially 250mg twice daily at 12-hour intervals for the first 2 weeks. Usual dose: 500mg–1g daily in divided doses monitored by blood levels. Max 1g/day.
Children
Not recommended.
Seromycin Contraindications
Contraindications
Epilepsy. Depression. Severe anxiety. Psychosis. Severe renal insufficiency. Excessive concurrent use of alcohol.
Seromycin Boxed Warnings
Not Applicable
Seromycin Warnings/Precautions
Warnings/Precautions
Discontinue or reduce dose if allergic dermatitis or CNS toxicity develops. Ratio of toxic dose to effective dose is small. Monitor blood levels, hematologic, renal, and liver function. Obtain weekly blood levels in patients with reduced renal function, patients receiving >500mg daily dosage, or those showing signs/symptoms suggestive of toxicity. Pregnancy (Cat.C). Nursing mothers: not recommended.
Seromycin Pharmacokinetics
See Literature
Seromycin Interactions
Interactions
Neurotoxic effects with concomitant ethionamide. Increased risk of epileptic episodes with alcohol. Increased CNS effects with concomitant isoniazid; monitor closely.
Seromycin Adverse Reactions
Adverse Reactions
CNS effects (eg, convulsions, drowsiness, somnolence, headache, tremor, dysarthria, vertigo, confusion, psychoses, character changes, hyperirritability, aggression, paresis, hyperreflexia, paresthesia, seizures, coma), CHF, allergy, rash, elevated serum transaminase (esp. with preexisting liver disease), anemia (monitor).
Seromycin Clinical Trials
See Literature
Seromycin Note
Not Applicable
Seromycin Patient Counseling
See Literature
