Reyataz

See Contraindications. Concomitant other protease inhibitors (excluding ritonavir and saquinavir), sofosbuvir/velpatasvir/voxilaprevir, colchicine (in those with renal or hepatic impairment), salmeterol: not recommended. Avoid atazanavir + ritonavir with boceprevir, fluticasone, rivaroxaban, voriconazole. Concomitant paclitaxel, repaglinide, carbamazepine, phenytoin, phenobarbital, bosentan, or buprenorphine without ritonavir: not recommended. Caution with UGT1A1 or CYP3A substrates (eg, IV midazolam, CCBs, statins [eg, atorvastatin, rosuvastatin (max 10mg/day); use lowest dose necessary], PDE5 inhibitors: reduce doses of these to treat ED; max 25mg sildenafil in 48hrs; max 2.5mg vardenafil in 24hrs [atazanavir] or 72hrs [atazanavir + ritonavir]; max 10mg tadalafil in 72hrs; tadalafil to treat PAH [see full labeling]). May be antagonized by CYP3A inducers. Consider reducing diltiazem or clarithromycin dose by 50%; rifabutin dose by 75%. Antagonized by H₂-blockers (see full labeling). Give PPIs 12hrs before atazanavir + ritonavir; avoid in therapy-experienced. Give 2hrs before or 1hr after antacids, didanosine buffered formulations. Antagonized by efavirenz, bosentan, tenofovir DF (see dose). Potentiates saquinavir, tenofovir DF, trazodone (caution), fluticasone, ketoconazole, itraconazole, buprenorphine (reduce dose), quetiapine (if co-administration needed, reduce quetiapine dose to 1/6 of current dose). Atazanavir + ritonavir may potentiate direct-acting oral anticoagulants (eg, betrixaban, dabigatran, edoxaban). Caution with oral contraceptives (eg, ethinyl estradiol + norgestimate or norethindrone). Concomitant other hormonal contraceptives (eg, patches, vaginal rings, injectables, other progestogen-containing products, or <25mcg ethinyl estradiol): use alternative methods. Monitor with antiarrhythmics, warfarin, tricyclics, rifabutin, apixaban, rivaroxaban, immunosuppressants. See full labeling.