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Retrovir Iv Generic Name & Formulations
Legal Class
Rx
General Description
Zidovudine 10mg/mL; for IV infusion after dilution; preservative-free.
Pharmacological Class
Nucleoside analogue (reverse transcriptase inhibitor).
How Supplied
Tabs—contact supplier; Caps—100; Syrup—240mL; IV (20mL/vial)—1, 5
Manufacturer
Generic Availability
YES
Retrovir Iv Indications
Indications
HIV-1 infection, in combination with other antiretroviral agents. Prevention of maternal-fetal HIV-1 transmission.
Retrovir Iv Dosage and Administration
Adult
Give by IV infusion over 1hr; use only until oral therapy can be given. 1mg/kg every 4hrs. Renal impairment (CrCL <15mL/min) or on dialysis: 1mg/kg every 6–8hrs. Prevention of maternal-fetal HIV or vertical transmission, severe anemia and/or neutropenia: see full labeling.
Children
Vertical transmission: see full labeling.
Retrovir Iv Contraindications
Not Applicable
Retrovir Iv Boxed Warnings
Boxed Warning
Hematological toxicity. Myopathy. Lactic acidosis and severe hepatomegaly with steatosis.
Retrovir Iv Warnings/Precautions
Warnings/Precautions
Risk of hematologic toxicity/bone marrow suppression; monitor CBCs esp. in advanced HIV-1 disease; interrupt dose if anemia or neutropenia occurs. Myopathy/myositis with prolonged use. Suspend if lactic acidosis or pronounced hepatotoxicity (eg, hepatomegaly, steatosis) occurs. Monitor for lipoatrophy; use alternatives if suspected. Severe renal impairment: reduce dose (see Adult). Hepatic impairment or cirrhosis: monitor for hematologic toxicity. Latex allergy (IV). Women. Obesity. Elderly. Pregnancy. Nursing mothers: not recommended.
Retrovir Iv Pharmacokinetics
See Literature
Retrovir Iv Interactions
Interactions
Avoid concomitant stavudine, doxorubicin, nucleoside analogues (eg, ribavirin). Increased hematologic toxicity with ganciclovir, interferon alpha, ribavirin, other bone marrow suppressants or cytotoxic drugs. Monitor for treatment-associated toxicities (eg, hepatic decompensation) with interferon alpha with or without ribavirin.
Retrovir Iv Adverse Reactions
Adverse Reactions
Headache, malaise, nausea, vomiting, anorexia; neutropenia, anemia, myopathy, lactic acidosis, severe hepatomegaly with steatosis, immune reconstitution syndrome, pancreatitis, lipoatrophy. Children: also fever, cough.
Retrovir Iv Clinical Trials
See Literature
Retrovir Iv Note
Not Applicable
Retrovir Iv Patient Counseling
See Literature
