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Raxibacumab Generic Name & Formulations
Legal Class
Rx
General Description
Raxibacumab 50mg/mL; soln for IV infusion after dilution; preservative-free.
Pharmacological Class
Monoclonal antibody.
How Supplied
Single-use vial (34mL)—1
Manufacturer
Generic Availability
NO
Raxibacumab Indications
Indications
Treatment of inhalational anthrax in combination with appropriate antibacterial drugs. Prophylaxis of inhalational anthrax when alternative therapies are not available or are not appropriate.
Limitations of Use
Has no direct antibacterial activity. Does not cross the blood-brain barrier. Does not prevent or treat meningitis. Pediatrics: safety and pharmacokinetics were not studied.
Raxibacumab Dosage and Administration
Adult
See full labeling. Premedicate with diphenhydramine (oral or IV) within 1hr prior to raxibacumab infusion. Give as IV infusion over 135mins. 40mg/kg.
Children
See full labeling. Premedicate with diphenhydramine (oral or IV) within 1hr prior to raxibacumab infusion. Give as IV infusion over 135mins. ≤10kg: 80mg/kg. >10–40kg: 60mg/kg. >40kg: 40mg/kg.
Raxibacumab Contraindications
Not Applicable
Raxibacumab Boxed Warnings
Boxed Warning
Hypersensitivity and anaphylaxis.
Raxibacumab Warnings/Precautions
Warnings/Precautions
Have resuscitative equipment and medication readily available. Monitor infusion during and after administration. Interrupt or discontinue if hypersensitivity reactions or anaphylaxis occur; treat appropriately. Pregnancy. Nursing mothers.
Raxibacumab Pharmacokinetics
See Literature
Raxibacumab Interactions
Not Applicable
Raxibacumab Adverse Reactions
Adverse Reactions
Rash, pain in extremity, pruritus, somnolence.
Raxibacumab Clinical Trials
See Literature
Raxibacumab Note
Not Applicable
Raxibacumab Patient Counseling
See Literature
