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Rapivab Generic Name & Formulations
Legal Class
Rx
General Description
Peramivir 10mg/mL; per vial; soln for IV inj after dilution; preservative-free.
Pharmacological Class
Neuraminidase inhibitor.
How Supplied
Single-use vials (20mL)—3
Manufacturer
Generic Availability
NO
Rapivab Indications
Indications
Treatment of acute uncomplicated influenza in patients who have been symptomatic for ≤2 days.
Limitations of Use
Efficacy based on predominantly influenza A virus infections; limited number of influenza B virus subjects were enrolled. Consider available information on influenza drug susceptibility patterns and treatment effects when deciding whether to use. Efficacy not established in patients with serious influenza requiring hospitalization.
Rapivab Dosage and Administration
Adult
Start within 2 days of symptom onset. Give as IV infusion over 15–30mins. ≥13yrs: 600mg as a single dose. Renal impairment (CrCl 30–49mL/min): 200mg; (CrCl 10–29mL/min): 100mg; (on hemodialysis): give after dialysis.
Children
<6months: not established. Start within 2 days of symptom onset. Give as IV infusion over 15–30mins. 6months–12yrs: 12mg/kg as a single dose (max 600mg). Renal impairment: 6months–<2yrs (CrCl <50mL/min): no data; 2–12yrs (CrCl 30–49mL/min): 4mg/kg; (CrCl 10–29mL/min): 2mg/kg; (on hemodialysis): give after dialysis.
Rapivab Contraindications
Not Applicable
Rapivab Boxed Warnings
Not Applicable
Rapivab Warnings/Precautions
Warnings/Precautions
Discontinue if anaphylaxis or serious skin reaction (eg, erythema multiforme, Stevens-Johnson syndrome) occurs or is suspected. Monitor closely for signs of abnormal behavior. Risk of secondary bacterial infections; treat as appropriate. Pregnancy. Nursing mothers.
Rapivab Pharmacokinetics
See Literature
Rapivab Interactions
Interactions
Avoid live attenuated influenza vaccine within 2wks prior or 48hrs after treatment.
Rapivab Adverse Reactions
Adverse Reactions
Diarrhea; neuropsychiatric events (eg, hallucinations, delirium, abnormal behavior); rare: serious skin reactions, anaphylaxis.
Rapivab Clinical Trials
See Literature
Rapivab Note
Not Applicable
Rapivab Patient Counseling
See Literature
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