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Pyrazinamide Generic Name & Formulations
Legal Class
Rx
General Description
Pyrazinamide 500mg; scored tabs.
Pharmacological Class
Nicotinamide analogue.
How Supplied
Contact supplier.
Manufacturer
Pyrazinamide Indications
Indications
Susceptible pulmonary tuberculosis.
Pyrazinamide Dosage and Administration
Adults and Children
15–30mg/kg once daily; max 2g daily. Or 50–70mg/kg twice weekly based on lean body weight.
Pyrazinamide Contraindications
Contraindications
Severe hepatic damage. Acute gout.
Pyrazinamide Boxed Warnings
Not Applicable
Pyrazinamide Warnings/Precautions
Warnings/Precautions
Use with other antituberculars. Monitor hepatic function and serum uric acid before and during therapy. Hepatocellular damage or hyperuricemia with acute gouty arthritis: discontinue. Patients at risk for hepatitis (eg, alcoholism). Diabetes (blood glucose may be harder to control). HIV: see literature. Pregnancy (Cat.C). Nursing mothers.
Pyrazinamide Pharmacokinetics
See Literature
Pyrazinamide Interactions
Interactions
May interfere with Acetest or Ketostix.
Pyrazinamide Adverse Reactions
Adverse Reactions
Hepatitis, liver dysfunction, gout, GI disturbances, arthralgia, myalgia, blood dyscrasias (rare).
Pyrazinamide Clinical Trials
See Literature
Pyrazinamide Note
Not Applicable
Pyrazinamide Patient Counseling
See Literature
