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Pentam 300 Generic Name & Formulations
Legal Class
Rx
General Description
Pentamidine isethionate 300mg/vial; lyophilized pwd for IM or IV inj after reconstitution.
Pharmacological Class
Aromatic diamidine.
How Supplied
Single-dose vials—10
Manufacturer
Pentam 300 Indications
Indications
Pneumonia due to Pneumocystis carinii.
Pentam 300 Dosage and Administration
Adults and Children
<4months: not recommended. Give by deep IM or IV inj. If administered by IV, must infused over 60–120 minutes. ≥4months: 4mg/kg once daily for 14–21 days. Therapy >21 days has been used; but may increase toxicity risk.
Pentam 300 Contraindications
Not Applicable
Pentam 300 Boxed Warnings
Not Applicable
Pentam 300 Warnings/Precautions
Warnings/Precautions
Hyper- or hypotension. Ventricular tachycardia. Hypo- or hyperglycemia. Hypocalcemia. Pancreatitis. Leukopenia. Thrombocytopenia. Anemia. Hepatic or renal dysfunction. Stevens-Johnson syndrome. Monitor BP, BUN, serum creatinine, blood glucose, CBC and platelets, liver function (eg, serum bilirubin, alkaline phosphatase, AST/ALT), serum calcium, ECG. Avoid extravasation. Have resuscitation equipment available. Pregnancy (Cat.C; avoid). Nursing mothers: not recommended.
Pentam 300 Pharmacokinetics
See Literature
Pentam 300 Interactions
Interactions
Additive effects with concomitant other nephrotoxic drugs (eg, aminoglycosides, amphotericin B, cisplatin, foscarnet, vancomycin); monitor closely or avoid if possible.
Pentam 300 Adverse Reactions
Adverse Reactions
Inj site reactions, severe hypotension, hypoglycemia, diabetes, acute pancreatitis, cardiac arrhythmias, nephrotoxic events (eg, renal dysfunction, elevated serum creatinine, azotemia, renal failure), leukopenia, elevated liver functions tests, anorexia/nausea, rash, pruritus.
Pentam 300 Clinical Trials
See Literature
Pentam 300 Note
Not Applicable
Pentam 300 Patient Counseling
See Literature
