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Oxacillin Inj Generic Name & Formulations
Legal Class
Rx
General Description
Oxacillin sodium 1g/vial, 2g/vial, 10g/vial; pwd for IM or IV inj after reconstitution, or IV drip after reconstitution and dilution; sodium content 2.5mEq/g oxacillin sodium.
Pharmacological Class
Penicillinase-resistant penicillin.
How Supplied
Contact supplier.
Manufacturer
Oxacillin Inj Indications
Indications
Susceptible infections due to penicillinase-producing staphylococci.
Oxacillin Inj Dosage and Administration
Adult
Give by IM gluteal inj, or slow IV inj over 10 mins, or IV drip. Mild-to-moderate infections: 250–500mg IM or IV every 4–6 hours. Severe infections: 1g IM or IV every 4–6 hours; treat for at least 14 days, then continue for at least 48 hours after becoming afebrile, asymptomatic, or (–) cultures. Endocarditis or osteomyelitis: may need longer therapy; see literature. Switch to oral therapy as soon as clinically indicated.
Children
Give by IM gluteal inj, or slow IV inj over 10 mins, or IV drip. Premature and neonates: 25mg/kg/day IM or IV. Infants and children <40kg: Mild-to-moderate infections: 50mg/kg/day IM or IV in divided doses every 6 hours; severe infections: 100mg/kg/day IM or IV in divided doses every 4–6 hours; treat for at least 14 days, then continue for at least 48 hours after becoming afebrile, asymptomatic, or (–) cultures. Endocarditis or osteomyelitis: may need longer therapy; see literature. Switch to oral therapy as soon as clinically indicated.
Oxacillin Inj Contraindications
Not Applicable
Oxacillin Inj Boxed Warnings
Not Applicable
Oxacillin Inj Warnings/Precautions
Warnings/Precautions
Cephalosporin or other allergy: not recommended. Asthma. Renal impairment: consider dose reduction. Do CBCs, BUN, urinalysis, creatinine levels prior to and weekly during therapy. Monitor renal, hepatic and hematopoietic function in prolonged use. Elderly (esp. IV route). Newborns (monitor). Pregnancy (Cat.B). Nursing mothers.
Oxacillin Inj Pharmacokinetics
See Literature
Oxacillin Inj Interactions
Interactions
May be antagonized by tetracycline; avoid. Potentiated by probenecid.
Oxacillin Inj Adverse Reactions
Adverse Reactions
Inj site reactions, rash, serum sickness, GI upset, anaphylaxis, neuropathy, nephropathy, blood dyscrasias, hepatotoxicity.
Oxacillin Inj Clinical Trials
See Literature
Oxacillin Inj Note
Notes
Formerly known under the brand name Bactocill.
Oxacillin Inj Patient Counseling
See Literature
