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Orbactiv Generic Name & Formulations
Legal Class
Rx
General Description
Oritavancin 400mg; per vial; lyophilized pwd for IV infusion after reconstitution and dilution; contains mannitol; preservative-free.
Pharmacological Class
Lipoglycopeptide.
How Supplied
Single-dose vials—3
Manufacturer
Generic Availability
NO
Orbactiv Indications
Indications
Susceptible acute bacterial skin and skin structure infections (ABSSSI).
Orbactiv Dosage and Administration
Adult
Give by IV infusion over 3hrs. ≥18yrs: 1200mg as a single dose.
Children
<18yrs: not established.
Orbactiv Contraindications
Contraindications
Use of IV unfractionated heparin sodium for 120hrs (5 days) after oritavancin administration.
Orbactiv Boxed Warnings
Not Applicable
Orbactiv Warnings/Precautions
Warnings/Precautions
History of glycopeptide allergy. Discontinue immediately if acute hypersensitivity reaction occurs. Stop or slow the infusion if infusion-related reactions occur. Evaluate if Clostridioides difficile-associated diarrhea is suspected or confirmed. Monitor for osteomyelitis; use alternative therapy if suspected or diagnosed. Severe hepatic or renal impairment: not studied. Pregnancy. Nursing mothers.
Orbactiv Pharmacokinetics
See Literature
Orbactiv Interactions
Interactions
Increased risk of bleeding with concomitant warfarin; may prolong aPTT for up to 120hrs, PT/INR for up to 12hrs, and ACT for up to 24hrs; monitor for bleeding. Avoid concomitant with drugs that are predominantly metabolized by one of the affected CYP450 enzymes. May increase concentrations of CYP2C9/CYP2C19 substrates. May decrease concentrations of CYP3A4/CYP2D6 substrates. May prolong certain lab coagulation tests; consider non-phospholipid dependent test (eg, Factor Xa assay) or alternative anticoagulant not requiring aPTT monitoring.
Orbactiv Adverse Reactions
Adverse Reactions
Headache, nausea, vomiting, limb and subcutaneous abscesses, diarrhea; infusion-related reactions.
Orbactiv Clinical Trials
See Literature
Orbactiv Note
Not Applicable
Orbactiv Patient Counseling
See Literature
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