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Nafcillin Generic Name & Formulations
Legal Class
Rx
General Description
Nafcillin sodium 1g/vial, 2g/vial, 10g/vial; pwd for deep IM inj after reconstitution, IV infusion after reconstitution and dilution.
Pharmacological Class
Penicillinase-resistant penicillin.
How Supplied
Contact supplier.
Manufacturer
Nafcillin Indications
Indications
Susceptible infections due to penicillinase-producing staphylococci.
Nafcillin Dosage and Administration
Adult
Give by deep IM gluteal inj or IV infusion over 30–60mins. IM: 500mg every 4–6hrs. IV: 500mg every 4hrs. Severe infections: 1g IM or IV every 4hrs; treat for at least 14 days, then continue for at least 48hrs after becoming afebrile, asymptomatic, or (–) cultures. Endocarditis or osteomyelitis: may need longer therapy; see full labeling. Switch to oral therapy as soon as clinically indicated.
Children
Give by deep IM gluteal inj only. Neonates: 10mg/kg twice daily. Infants and children (<40kg): 25mg/kg twice daily.
Nafcillin Contraindications
Not Applicable
Nafcillin Boxed Warnings
Not Applicable
Nafcillin Warnings/Precautions
Warnings/Precautions
Cephalosporin allergy: not recommended. History of significant allergies. Asthma. Discontinue if superinfection occurs or if CDAD is suspected or confirmed. Obtain CBCs, BUN, urinalysis, creatinine, LFTs at baseline and periodically during therapy. Monitor renal, hepatic and hematopoietic function in prolonged use. Renal and hepatic impairment. Elderly (esp. IV route). Pregnancy. Nursing mothers.
Nafcillin Pharmacokinetics
See Literature
Nafcillin Interactions
Interactions
May be antagonized by tetracycline; avoid. Concomitant warfarin: monitor; adjust dose as needed. May antagonize cyclosporine; monitor. Potentiated by probenecid. May cause false (+) protein urine test with sulfosalicyclic acid.
Nafcillin Adverse Reactions
Adverse Reactions
Inj site reactions, thrombophlebitis, rash, serum sickness, GI upset, neurotoxicity, renal toxicity, elevated LFTs, blood dyscrasias; hypersensitivity reactions, CDAD, pseudomembranous colitis.
Nafcillin Clinical Trials
See Literature
Nafcillin Note
Notes
Formerly known under the brand names Nallpen, Unipen.
Nafcillin Patient Counseling
See Literature
