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Moxidectin Generic Name & Formulations
Legal Class
Rx
General Description
Moxidectin 2mg; tabs.
Pharmacological Class
Anthelmintic.
How Supplied
Tabs—500
Manufacturer
Moxidectin Indications
Indications
Onchocerciasis due to Onchocerca volvulus.
Limitations of Use
Does not kill adult O. volvulus parasites; follow-up advised. Safety and efficacy of repeat administration not studied.
Moxidectin Dosage and Administration
Adult
8mg (4 tabs) as a single dose.
Children
<12yrs: not established.
Moxidectin Contraindications
Not Applicable
Moxidectin Boxed Warnings
Not Applicable
Moxidectin Warnings/Precautions
Warnings/Precautions
Risk of cutaneous, ophthalmological and/or systemic reactions (Mazzotti reaction) esp. in those with higher microfilarial burden; treat appropriately. Serious encephalopathy may occur if co-infected with Loa loa; screen for loiasis in endemic areas prior to treatment. Possible severe edema and worsening onchodermatitis in those with hyper-reactive onchodermatitis. Severe renal impairment, ESRD. Pregnancy. Nursing mothers: not recommended (during and for 7 days after treatment).
Moxidectin Pharmacokinetics
See Literature
Moxidectin Interactions
Not Applicable
Moxidectin Adverse Reactions
Adverse Reactions
Eosinophilia, pruritus, musculoskeletal pain, headache, lymphopenia,
tachycardia, rash, abdominal pain, hypotension, pyrexia, leukocytosis,
influenza-like illness, neutropenia, cough, lymph node pain, dizziness,
diarrhea, hyponatremia, peripheral swelling.
Moxidectin Clinical Trials
See Literature
Moxidectin Note
Not Applicable
Moxidectin Patient Counseling
See Literature
