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Merrem Generic Name & Formulations
Legal Class
Rx
General Description
Meropenem 500mg, 1g; pwd for IV inj after reconstitution; sodium content 3.92mEq/g.
Pharmacological Class
Carbapenem.
How Supplied
Single-use vials—1
Manufacturer
Generic Availability
YES
Merrem Indications
Indications
Susceptible infections including complicated skin and skin structure infections (SSSI), intraabdominal infections, bacterial meningitis.
Merrem Dosage and Administration
Adult
Give by IV infusion over 15–30mins or IV bolus over 3–5mins (for doses = 1g). SSSI: 500mg every 8hrs. P. aeruginosa associated SSSI, intraabdominal: 1g every 8hrs. Renal impairment: CrCl 26–50mL/min: give recommended dose every 12hrs; CrCl 10–25mL/min: give ½ of recommended dose every 12hrs; CrCl <10mL/min: give ½ of recommended dose every 24hrs.
Children
<3mos: give by IV infusion over 30mins. Intraabdominal: <32 weeks gestational age (GA) and <2 weeks postnatal age (PNA): 20mg/kg every 12hrs; <32 weeks GA and ≥2 weeks PNA or ≥32 weeks GA and <2 weeks PNA: 20mg/kg every 8hrs; ≥32 weeks GA and ≥2 weeks PNA: 30mg/kg every 8hrs. ≥3mos: give by IV infusion over 15–30mins or IV bolus over 3–5mins. SSSI: 10mg/kg (>50kg: max 500mg) every 8hrs. P. aeruginosa associated SSSI, intraabdominal: 20mg/kg (>50kg: max 1g) every 8hrs. Meningitis: 40mg/kg (>50kg: max 2g) every 8hrs. >50kg: give max dosing per indication.
Merrem Contraindications
Contraindications
β-lactam allergy.
Merrem Boxed Warnings
Not Applicable
Merrem Warnings/Precautions
Warnings/Precautions
CNS disorders. History of seizures. Discontinue if severe skin reactions (eg, SJS, TEN, DRESS) occur; consider alternatives. Renal impairment. Hemodialysis or peritoneal dialysis. Pregnancy. Nursing mothers.
Merrem Pharmacokinetics
See Literature
Merrem Interactions
Interactions
Potentiated by probenecid: not recommended. Avoid concomitant valproic acid; if needed, consider supplemental anticonvulsant.
Merrem Adverse Reactions
Adverse Reactions
Headache, nausea, constipation, diarrhea, anemia, vomiting, rash (may be severe); C. difficile-associated diarrhea, possible neuromotor impairment (eg, seizures, delirium, paresthesias), hypersensitivity reactions, superinfection (with prolonged use).
Merrem Clinical Trials
See Literature
Merrem Note
Not Applicable
Merrem Patient Counseling
See Literature
