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Mepron Generic Name & Formulations
Legal Class
Rx
General Description
Atovaquone 750mg/5mL; oral susp; citrus flavor.
Pharmacological Class
Naphthoquinone.
How Supplied
Susp—210mL
Manufacturer
Mepron Indications
Indications
Treatment of mild-to-moderate Pneumocystis jirovecii pneumonia (PCP) in patients intolerant to trimethoprim/sulfamethoxazole (TMP/SMX). Prevention of PCP in patients intolerant to TMP/SMX.
Limitations of Use
Treatment of more severe PCP has not been studied. Mepron's efficacy has not been studied in those who are failing therapy with TMP/SMX.
Mepron Dosage and Administration
Adult
Take with food. ≥13yrs: Treatment: 750mg twice daily for 21 days. Prophylaxis: 1500mg once daily.
Children
<13yrs: not established.
Mepron Contraindications
Not Applicable
Mepron Boxed Warnings
Not Applicable
Mepron Warnings/Precautions
Warnings/Precautions
GI disorders or inability to take with food. Monitor in severe hepatic impairment. Elderly. Pregnancy (Cat.C). Nursing mothers.
Mepron Pharmacokinetics
See Literature
Mepron Interactions
Interactions
Concomitant rifampin or rifabutin: not recommended. Antagonized by tetracycline; caution and monitor if use is needed. May be antagonized by metoclopramide (use only if other antiemetics are not available). Antagonizes indinavir; caution and monitor if use is needed.
Mepron Adverse Reactions
Adverse Reactions
Diarrhea, rash, headache, nausea, fever, rhinitis, vomiting, sweating, flu syndrome, sinusitis, pruritus, insomnia, depression, myalgia.
Mepron Clinical Trials
See Literature
Mepron Note
Not Applicable
Mepron Patient Counseling
See Literature
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