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Mefloquine Tablets Generic Name & Formulations
Legal Class
Rx
General Description
Mefloquine (as HCl) 250mg; scored tabs.
Pharmacological Class
Aminoquinoline.
How Supplied
Contact supplier.
Manufacturer
Mefloquine Tablets Indications
Indications
Prophylaxis of P. falciparum (including chloroquine-resistant strains) and P. vivax malaria. Treatment of mild to moderate acute malaria due to susceptible strains of P. falciparum or P. vivax.
Mefloquine Tablets Dosage and Administration
Adult
Take with food and 8oz water. Prophylaxis: 250mg once weekly starting 1 week before departure, continuing during travel to endemic areas and for 4 weeks after return. Treatment: 1250mg as a single dose.
Children
Give with food and water. May crush tab and mix in water. Prophylaxis: 3–5mg/kg once weekly starting 1 week before departure, continuing during travel to endemic areas and for 4 weeks after return. Treatment: ≤6months of age: contact manufacturer. ≥6months: 20–25mg/kg as single dose or as 2 doses 6–8 hours apart.
Mefloquine Tablets Contraindications
Contraindications
Quinine, quinidine, or related allergy. Not for prophylactic use in patients with psychiatric disorders or history of depression or seizures.
Mefloquine Tablets Boxed Warnings
Not Applicable
Mefloquine Tablets Warnings/Precautions
Warnings/Precautions
Do not use for life-threatening P. falciparum infection. After initial treatment for acute P. vivax infection, follow with an 8-aminoquinoline (eg, primaquine) to eliminate exoerythrocytic phase. Discontinue prophylactic therapy if unexplained CNS disturbances occur. Cardiac disease. Psychiatric disturbances. Seizure disorders. Hepatic impairment. Monitor liver, visual function in long-term use. Pregnancy (Cat.C); use adequate contraception. Nursing mothers: not recommended.
Mefloquine Tablets Pharmacokinetics
See Literature
Mefloquine Tablets Interactions
Interactions
Do not use during or within 12 hours of quinine, quinidine, chloroquine (may cause seizures or ECG changes); caution with drugs that cause QTc prolongation (eg, β-blockers). Do not use halofantrine or ketoconazole during or within 15 weeks of last mefloquine dose. Caution with rifampin. May affect or be affected by CYP3A4 inhibitors or inducers, p-glycoprotein substrates. May antagonize antiepileptics. Complete live oral bacterial vaccinations (eg, typhoid) at least 3 days before 1st mefloquine dose. Monitor anticoagulants, antidiabetics, antiepileptics 2–3 weeks before departure.
Mefloquine Tablets Adverse Reactions
Adverse Reactions
Vomiting, dizziness, vertigo, syncope, extrasystoles, myalgias, fever, headache, chills, diarrhea, rash, abdominal pain, fatigue, anorexia, tinnitus; rare: seizures, cardiac arrest, encephalopathy, CNS/emotional disturbances.
Mefloquine Tablets Clinical Trials
See Literature
Mefloquine Tablets Note
Not Applicable
Mefloquine Tablets Patient Counseling
See Literature
