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Macrodantin Generic Name & Formulations
Legal Class
Rx
General Description
Nitrofurantoin macrocrystals 25mg, 50mg, 100mg; caps.
Pharmacological Class
Antibiotic.
How Supplied
Caps—100
Manufacturer
Macrodantin Indications
Indications
Susceptible UTIs.
Macrodantin Dosage and Administration
Adult
Take with food. 50–100mg 4 times daily for at least 7 days. Long-term use: 50–100mg at bedtime.
Children
Take with food. <1 month: not recommended. ≥1 month: 5–7mg/kg per day in 4 divided doses for at least 7 days. Long-term use: 1mg/kg per day in 1–2 divided doses.
Macrodantin Contraindications
Contraindications
Anuria, oliguria, CrCl <60mL/min. Neonates <1 month of age. Labor & delivery. Pregnancy at term. History of cholestatic jaundice/hepatic dysfunction associated with nitrofurantoin.
Macrodantin Boxed Warnings
Not Applicable
Macrodantin Warnings/Precautions
Warnings/Precautions
Not for treating pyelonephritis or perinephric abscesses. Discontinue if pulmonary reactions, hepatic disorders, or hemolysis occurs. Renal insufficiency; monitor (esp. in elderly). G6PD or Vit. B deficiency. Anemia. Diabetes. Electrolyte imbalance. Monitor renal function and pulmonary condition in long-term use. Debilitated. Pregnancy (Cat.B). Nursing mothers: not recommended.
Macrodantin Pharmacokinetics
See Literature
Macrodantin Interactions
Interactions
Reduced absorption by magnesium trisilicate. Uricosurics (eg, probenecid, sulfinpyrazone) may inhibit tubular secretion. May cause false (+) glucose test with Benedict's or Fehling's solution.
Macrodantin Adverse Reactions
Adverse Reactions
Nausea, headache, dizziness, anorexia, alopecia; C. diff-associated diarrhea, pulmonary disorders, hepatic damage, hemolytic anemia, peripheral neuropathy (may be irreversible), anaphylaxis, blood dyscrasias; rare: exfoliative dermatitis, Stevens-Johnson syndrome, aplastic anemia.
Macrodantin Clinical Trials
See Literature
Macrodantin Note
Not Applicable
Macrodantin Patient Counseling
See Literature
