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Lincocin Generic Name & Formulations
Legal Class
Rx
General Description
Lincomycin 300mg/mL; soln for IV, IM, subconjunctival inj after dilution; contains benzyl alcohol 9.45mg.
Pharmacological Class
Lincosamide.
How Supplied
Vials (2mL, 10mL)—1
Manufacturer
Generic Availability
YES
Lincocin Indications
Indications
Serious infections due to susceptible strains of streptococci, pneumococci, and staphylococci. Reserved for penicillin-allergic patients or for whom penicillin is inappropriate.
Lincocin Dosage and Administration
Adult
IV doses: infuse over ≥60mins. Do not administer as an IV bolus. Serious infections: 600mg IM every 24hrs or 600mg–1g IV every 8–12hrs. More severe infections: 600mg IM every 12hrs (or more often), or doses up to max 8g/day IV have been used for life-threatening infections. Subconjunctival inj: 75mg subconjunctivally will result in ocular fluid levels of antibiotic with MICs sufficient for most susceptible pathogens. Severe renal impairment: give 25–30% of recommended dose.
Children
<1month: not established. IV doses: infuse over ≥60mins. Do not administer as an IV bolus. ≥1month: Serious infections: 10mg/kg IM every 24hrs. More severe infections: 10mg/kg IM every 12hrs or more often. Depending on severity of infection, may also give 10–20mg/kg/day IV in divided doses.
Lincocin Contraindications
Contraindications
Clindamycin hypersensitivity.
Lincocin Boxed Warnings
Boxed Warning
Clostridioides difficile associated diarrhea.
Lincocin Warnings/Precautions
Warnings/Precautions
Risk of severe colitis (may be fatal); consider C. difficile-associated diarrhea (CDAD) in all patients presenting with diarrhea after use; discontinue if CDAD suspected/confirmed or if significant diarrhea occurs. Not for treating minor bacterial or viral infections, or meningitis. History of GI disease (esp. colitis). History of asthma or significant allergies. Severe renal impairment. Hepatic dysfunction. Monitor liver, kidney, and blood counts with prolonged and high-dose therapy. Premature or low-birth weight infants (gasping syndrome from benzyl alcohol). Pregnancy. Nursing mothers: not recommended.
Lincocin Pharmacokinetics
See Literature
Lincocin Interactions
Interactions
Concomitant erythromycin: not recommended. May potentiate neuromuscular blocking agents.
Lincocin Adverse Reactions
Adverse Reactions
Nausea, vomiting, diarrhea, colitis, hematologic effects (eg, neutropenia, leukopenia, agranulocytosis, thrombocytopenic purpura), rash, urticaria, vaginitis, jaundice, abnormal LFTs, azotemia, oliguria, proteinuria, cardiopulmonary arrest and hypotension with rapid IV administration, superinfection; CDAD, hypersensitivity or severe skin reactions (discontinue if occur).
Lincocin Clinical Trials
See Literature
Lincocin Note
Not Applicable
Lincocin Patient Counseling
See Literature
