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Isoniazid Generic Name & Formulations
Legal Class
Rx
General Description
Isoniazid 300mg; scored tabs.
Pharmacological Class
Isonicotinic acid.
How Supplied
Contact supplier.
Manufacturer
Isoniazid Indications
Indications
Prophylaxis and treatment of susceptible tuberculosis.
Isoniazid Dosage and Administration
Adult
Prophylaxis: 300mg once daily. Active infection: 5mg/kg daily; max 300mg once daily. Do not interrupt therapy.
Children
Prophylaxis: 10mg/kg once daily; max 300mg daily. Active infection: 10–20mg/kg once daily; max 500mg daily. Do not interrupt therapy.
Isoniazid Contraindications
Contraindications
Drug-induced hepatitis. Previous isoniazid-associated hepatic injury. Severe adverse reactions to isoniazid (eg, drug fever, chills, arthritis). Acute liver disease of any etiology.
Isoniazid Boxed Warnings
Not Applicable
Isoniazid Warnings/Precautions
Warnings/Precautions
Impaired renal or hepatic function. Monitor hepatic and ocular function. Alcoholism. Diabetes. Increased risk of liver damage with increasing age. Multiple drug therapy and concomitant pyridoxine may be necessary. Pregnancy. Nursing mothers.
Isoniazid Pharmacokinetics
See Literature
Isoniazid Interactions
Interactions
Potentiates phenytoin. Alcohol increases risk of hepatitis. Pyridoxine deficiency increases risk of neuropathy.
Isoniazid Adverse Reactions
Adverse Reactions
Peripheral neuropathy (esp. in slow acetylators), elevated serum transaminases (SGOT; SGPT), bilirubinemia, bilirubinuria, jaundice, hepatitis (may be fatal), nausea, vomiting, epigastric distress, pancreatitis, blood dyscrasias, hypersensitivity reactions (eg, skin eruptions, TEN, DRESS), pyridoxine deficiency, hyperglycemia, pellagra, metabolic acidosis, gynecomastia, rheumatic syndrome, SLE-like syndrome.
Isoniazid Clinical Trials
See Literature
Isoniazid Note
Notes
Formerly known under the brand names INH, Laniazid.
Isoniazid Patient Counseling
See Literature
