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Imipenem And Cilastatin Sodium 250mg Generic Name & Formulations
Legal Class
Rx
General Description
Imipenem 250mg, cilastatin sodium 250mg; pwd for IV infusion after reconstitution and dilution; sodium content 18.8mg (0.8mEq).
Pharmacological Class
Carbapenem (thienamycin) + dehydropeptidase I inhibitor.
See Also
How Supplied
Single-dose vials 250mg—contact supplier; 500mg—25
Manufacturer
Imipenem And Cilastatin Sodium 250mg Indications
Indications
Serious susceptible infections including bacterial septicemia, lower respiratory tract, urinary tract, skin and skin structure, bone and joint, intraabdominal, gynecologic, endocarditis.
Imipenem And Cilastatin Sodium 250mg Dosage and Administration
Adult
Base dose on imipenem component. Give by IV infusion only. Infuse over 20–30mins (500mg) or 40–60mins (1000mg); slower rate if nausea/vomiting occurs. Susceptible bacteria: 500mg every 6hrs or 1000mg every 8hrs. Intermediate susceptibility: 1000mg every 6hrs. Max 4g/day. Renal impairment (CrCl <90mL/min): reduce dose; see full labeling. CrCl <15mL/min: not recommended unless hemodialysis starts within 48hrs. Hemodialysis: give after session (see full labeling).
Children
<30kg with renal impairment or CNS infections (seizure risk): not recommended. Base dose on imipenem component. Give by IV infusion only. Infuse over 20–30mins (if ≤500mg) or 40–60mins (if >500mg); slower rate if nausea/vomiting occurs. Non-CNS infections (if ≥1.5kg): <1wk of age: 25mg/kg every 12hrs; 1–4wks: 25mg/kg every 8hrs; 4wks–3mos: 25mg/kg every 6hrs; ≥3mos: 15–25mg/kg every 6hrs. Max 4g/day.
Imipenem And Cilastatin Sodium 250mg Contraindications
Not Applicable
Imipenem And Cilastatin Sodium 250mg Boxed Warnings
Not Applicable
Imipenem And Cilastatin Sodium 250mg Warnings/Precautions
Warnings/Precautions
Not for the treatment of meningitis. Penicillin, cephalosporin, β-lactam, or other allergy. CNS disorders (esp. brain lesions or history of seizures). Monitor renal, hepatic, hematologic function periodically with prolonged use. Renal impairment. Pregnancy. Nursing mothers.
Imipenem And Cilastatin Sodium 250mg Pharmacokinetics
See Literature
Imipenem And Cilastatin Sodium 250mg Interactions
Interactions
Concomitant ganciclovir (increased seizure risk), probenecid: not recommended. May antagonize valproic acid; consider alternative; if co-administration needed, consider supplemental anticonvulsant.
Imipenem And Cilastatin Sodium 250mg Adverse Reactions
Adverse Reactions
Phlebitis, nausea, diarrhea, vomiting, rash, inj site reactions, fever, hypotension, seizures, dizziness, pruritus, vein induration, urticaria, somnolence; C. difficile-associated diarrhea, hypersensitivity reactions (discontinue if occur). Children: also gastroenteritis, discolored urine, oliguria/anuria, oral candidiasis, tachycardia.
Imipenem And Cilastatin Sodium 250mg Clinical Trials
See Literature
Imipenem And Cilastatin Sodium 250mg Note
Not Applicable
Imipenem And Cilastatin Sodium 250mg Patient Counseling
See Literature
