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Gentamicin Inj Generic Name & Formulations
Legal Class
Rx
General Description
Gentamicin sulfate 40mg/mL; IM, or IV inj after dilution; contains sulfites.
Pharmacological Class
Aminoglycoside.
How Supplied
Contact supplier.
Manufacturer
Gentamicin Inj Indications
Indications
Serious susceptible infections.
Gentamicin Inj Dosage and Administration
Adult
Obesity: Base dose on lean body mass. Usual duration 7–10 days. 1mg/kg IM or IV every 8 hours; max 5mg/kg/day. For alternative dosing regimens (eg, extended intervals) see literature.
Children
Premature and infants <1 week: 2.5mg/kg every 12 hours. Neonates: 2.5mg/kg every 8 hours. Others: 2–2.5mg/kg every 8 hours.
Gentamicin Inj Contraindications
Not Applicable
Gentamicin Inj Boxed Warnings
Not Applicable
Gentamicin Inj Warnings/Precautions
Warnings/Precautions
Monitor for nephro- and neurotoxicity; avoid peak serum levels >12micrograms/mL (when dosed at conventional intervals) and trough levels >2micrograms/mL. Renal impairment: reduce dose, see literature; maintain adequate hydration. Prolonged use or excessive doses. Asthma. Neuromuscular disorders. Elderly. Pregnancy (Cat.D): not recommended.
Gentamicin Inj Pharmacokinetics
See Literature
Gentamicin Inj Interactions
Interactions
Avoid concomitant furosemide, ethacrynic acid, other nephro/neurotoxic drugs including cephalosporins. May potentiate neuromuscular blockade.
Gentamicin Inj Adverse Reactions
Adverse Reactions
Nephro- or neurotoxicity, respiratory depression, lethargy, confusion, depression, visual disturbances, elevated liver enzymes, blood dyscrasias.
Gentamicin Inj Clinical Trials
See Literature
Gentamicin Inj Note
Notes
Formerly known under the brand names Garamycin, Gentafair.
Gentamicin Inj Patient Counseling
See Literature
