FURADANTIN Dosage & Rx Info | Uses, Side Effects

Furadantin Generic Name & Formulations

Legal Class

General Description

Nitrofurantoin 25mg/5mL, 50mg/5mL; susp.

Pharmacological Class

Antibiotic.

How Supplied

Susp (25mg/5mL)—230mL; (50mg/5mL)—60mL

Storage

Store between 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F). Protect from freezing.

Manufacturer

Casper Pharma

Generic Availability

YES

Mechanism of Action

Nitrofurantoin is reduced by a wide range of enzymes including bacterial flavoproteins to reactive intermediates which are damaging to macromolecules such as DNA and proteins.

Furadantin Indications

Indications

Susceptible UTIs.

Limitations of Use

Not for treating pyelonephritis or perinephric abscesses.

Furadantin Dosage and Administration

Adult

Take with food. 50–100mg 4 times daily. Suppressive therapy: 50–100mg once daily at bedtime may suffice.

Children

Take with food. <1month: contraindicated. ≥1month: 5–7mg/kg per day in 4 divided doses; if ≥40kg, see Adult dose. Continue therapy for 1 week or for at least 3 days until urine is sterile. Suppressive therapy: 1mg/kg per day in 1–2 divided doses may suffice.

Furadantin Contraindications

Contraindications

Renal impairment (CrCl <60mL/min or significantly elevated serum creatinine), anuria, oliguria. Neonates <1 month of age. Labor & delivery. Pregnancy at term (38–42 weeks gestation). History of cholestatic jaundice or hepatic dysfunction.

Furadantin Boxed Warnings

Not Applicable

Furadantin Warnings/Precautions

Warnings/Precautions

Discontinue and treat appropriately if hypersensitivity or pulmonary reactions, hepatitis, or hemolysis occurs. Monitor LFTs periodically. Renal insufficiency. G6PD or Vit. B deficiency. Anemia. Diabetes. Electrolyte imbalance. Debilitated. Monitor renal and pulmonary function in long-term use. Nursing mothers: not recommended (monitor infants).

Furadantin Pharmacokinetics

Distribution

Serum protein bound: ~90%.

Metabolism

Hepatic.

Elimination

Renal. Half-life: 0.72–0.78 hours.

Furadantin Interactions

Interactions

Avoid magnesium trisilicate. Antagonized by, and increased toxicity with uricosurics (eg, probenecid, sulfinpyrazone). May cause false (+) glucose test with Benedict's or Fehling's solution.

Furadantin Adverse Reactions

Adverse Reactions

Nausea, emesis, anorexia, dizziness, headache, pulmonary reactions (esp. in long-term use), peripheral neuropathy, allergic reactions, C. difficile-associated diarrhea, hematologic disorders; rare: hepatic reactions, exfoliative dermatitis, Stevens-Johnson syndrome, optic neuritis, methemoglobinemia, aplastic anemia.

Furadantin Clinical Trials

See Literature

Furadantin Note