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Eryped Generic Name & Formulations
Legal Class
Rx
General Description
Erythromycin (as ethylsuccinate) 200mg/5mL (fruit flavor) 400mg/5mL, (banana flavor); oral susp.
Pharmacological Class
Macrolide.
How Supplied
Susp—100mL
Manufacturer
Eryped Indications
Indications
Treatment of susceptible infections including upper and lower respiratory, skin and skin structure, genitourinary, Legionnaires' disease, pertussis, listeriosis. Prophylaxis for rheumatic fever attacks in penicillin-allergic patients.
Eryped Dosage and Administration
Adult
Usual dose: 400mg every 6hrs; max 4g/day. May give daily dose in 2 or 3 evenly divided doses. Legionnaires: 1.6–4g/day in divided doses. Prophylaxis: 400mg twice daily. See full labeling.
Children
Mild-to-moderate infections: 30–50mg/kg/day in 2, 3, or 4 evenly divided doses; may double dose in severe infections. See full labeling.
Eryped Contraindications
Contraindications
Concomitant terfenadine, astemizole, cisapride, pimozide, ergotamine, dihydroergotamine, statins (eg, lovastatin, simvastatin).
Eryped Boxed Warnings
Not Applicable
Eryped Warnings/Precautions
Warnings/Precautions
Avoid in proarrhythmic conditions (eg, uncorrected hypokalemia or hypomagnesemia, clinically significant bradycardia); risk of QT prolongation. Myasthenia gravis. Hepatic impairment. Elderly. Infants: risk of infantile hypertrophic pyloric stenosis; monitor for vomiting or irritability with feeding. Pregnancy (Cat.B). Nursing mothers.
Eryped Pharmacokinetics
See Literature
Eryped Interactions
Interactions
See Contraindications. May potentiate theophylline (reduce dose of theophylline), digoxin, oral anticoagulants, hexobarbital, phenytoin, valproate. May potentiate CYP3A substrates (eg, triazolam, midazolam, statins [rhabdomyolysis], sildenafil [reduce dose of sildenafil], colchicine [reduce starting dose of colchicine, max dose should be lowered; monitor], verapamil, amlodipine, diltiazem, carbamazepine, cyclosporine, tacrolimus, alfentanil, disopyramide, bromocriptine, rifabutin, quinidine, methylprednisolone, cilostazol, vinblastine); consider dose adjustments and monitor. May be antagonized by theophylline. Hypotension, bradyarrhythmias, lactic acidosis with verapamil. QT prolongation with concomitant Class 1A (quinidine, procainamide) or Class III (dofetilide, amiodarone, sotalol) antiarrhythmics; avoid. May interfere with fluorometric detection of urinary catecholamines.
Eryped Adverse Reactions
Adverse Reactions
GI upset, abdominal pain, anorexia, hepatic dysfunction; QT prolongation, C. difficile-associated diarrhea, superinfection (discontinue if occurs).
Eryped Clinical Trials
See Literature
Eryped Note
Not Applicable
Eryped Patient Counseling
See Literature
