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Eryc Generic Name & Formulations
Legal Class
Rx
General Description
Erythromycin (as base) 250mg; e-c pellets in caps.
Pharmacological Class
Macrolide.
How Supplied
Caps—100
Manufacturer
Eryc Indications
Indications
Treatment of susceptible infections including upper and lower respiratory, skin and skin structure, genitourinary, Legionnaires' disease, pertussis, listeriosis. Prophylaxis for rheumatic fever attacks in penicillin-allergic patients.
Eryc Dosage and Administration
Adult
Give 1hr before meals. Usual dose: 250mg every 6hrs or 500mg every 12hrs; max 4g/day (1g/day for twice daily dosing). Legionnaires: 1–4g/day in divided doses. Prophylaxis: 250mg twice daily. See full labeling.
Children
Give 1hr before meals. Usual dose: 30–50mg/kg/day in divided doses; may double dose in severe infections. See full labeling.
Eryc Contraindications
Contraindications
Concomitant terfenadine, astemizole, cisapride, pimozide, ergotamine, dihydroergotamine, statins (eg, lovastatin, simvastatin).
Eryc Boxed Warnings
Not Applicable
Eryc Warnings/Precautions
Warnings/Precautions
Avoid in proarrhythmic conditions (eg, uncorrected hypokalemia or hypomagnesemia, clinically significant bradycardia); risk of QT prolongation. Myasthenia gravis. Hepatic impairment. Elderly. Infants: risk of infantile hypertrophic pyloric stenosis; monitor for vomiting or irritability with feeding. Pregnancy (Cat.B). Nursing mothers.
Eryc Pharmacokinetics
See Literature
Eryc Interactions
Interactions
See Contraindications. May potentiate theophylline (reduce dose of theophylline), digoxin, oral anticoagulants, hexobarbital, phenytoin, valproate. May potentiate CYP3A substrates (eg, triazolam, midazolam, statins [rhabdomyolysis], sildenafil [reduce dose of sildenafil], colchicine [reduce starting dose of colchicine, max dose should be lowered; monitor], verapamil, amlodipine, diltiazem, carbamazepine, cyclosporine, tacrolimus, alfentanil, disopyramide, bromocriptine, rifabutin, quinidine, methylprednisolone, cilostazol, vinblastine); consider dose adjustments and monitor. May be antagonized by theophylline. Hypotension, bradyarrhythmias, lactic acidosis with verapamil. QT prolongation with concomitant Class 1A (quinidine, procainamide) or Class III (dofetilide, amiodarone, sotalol) antiarrhythmics; avoid. May interfere with fluorometric detection of urinary catecholamines.
Eryc Adverse Reactions
Adverse Reactions
GI upset, abdominal pain, anorexia, hepatic dysfunction; QT prolongation, C. difficile-associated diarrhea, superinfection (discontinue if occurs).
Eryc Clinical Trials
See Literature
Eryc Note
Not Applicable
Eryc Patient Counseling
See Literature
