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Eraxis Generic Name & Formulations
Legal Class
Rx
General Description
Anidulafungin 50mg/vial, 100mg/vial; lyophilized pwd for IV infusion after reconstitution and dilution; preservative-free; contains fructose, mannitol, polysorbate 80.
Pharmacological Class
Glucan synthesis inhibitor (echinocandin).
How Supplied
Single-dose vial—1
Manufacturer
Generic Availability
NO
Eraxis Indications
Indications
Candidemia and other Candida infections (intra-abdominal abscess, peritonitis) in patients ≥1month of age. Esophageal candidiasis in adults.
Limitations of Use
Not been studied in those with endocarditis, osteomyelitis, and meningitis due to Candida, or in sufficient numbers of neutropenic patients to determine efficacy. Dosage for treatment of Candida dissemination into the CNS and the eye has not been established.
Eraxis Dosage and Administration
Adult
Give by IV infusion; max rate 1.1mg/min. Candidemia and other Candida infections: 200mg on day 1, then 100mg/day for at least 14 days after last positive culture. Esophageal candidiasis: 100mg on day 1, then 50mg/day for at least 14 days and at least 7 days after symptom resolution.
Children
<1month: not established. Give by IV infusion; max rate 1.1mg/min. ≥1month: 3mg/kg (max 200mg) on day 1, then 1.5mg/kg/day (max 100mg/day) for at least 14 days after last positive culture.
Eraxis Contraindications
Contraindications
Hereditary fructose intolerance (HFI).
Eraxis Boxed Warnings
Not Applicable
Eraxis Warnings/Precautions
Warnings/Precautions
Follow-up if abnormal LFTs develop; evaluate for continued therapy. Discontinue and treat appropriately if anaphylactic reactions occur. Obtain history of HFI symptoms prior to initiation (esp. children). Neonates: risk of polysorbate toxicity. Pregnancy. Nursing mothers.
Eraxis Pharmacokinetics
See Literature
Eraxis Interactions
Not Applicable
Eraxis Adverse Reactions
Adverse Reactions
Hypokalemia, GI upset, pyrexia, insomnia, hypotension, anemia, headache, dyspepsia, oral candidiasis; children: also abdominal pain, thrombocytopenia, increased ALT/AST, hypoglycemia, epistaxis, rash.
Eraxis Clinical Trials
See Literature
Eraxis Note
Not Applicable
Eraxis Patient Counseling
See Literature
