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Dalvance Generic Name & Formulations
Legal Class
Rx
General Description
Dalbavancin 500mg; per vial; lyophilized pwd for IV infusion after reconstitution and dilution; preservative-free.
Pharmacological Class
Lipoglycopeptide.
How Supplied
Single-use vial—1
Manufacturer
Generic Availability
NO
Dalvance Indications
Indications
Susceptible acute bacterial skin and skin structure infections (ABSSSI).
Dalvance Dosage and Administration
Adult
Give by IV infusion over 30mins. CrCl ≥30mL/min: administer 1500mg as single dose, or 1000mg followed by 500mg one week later. Renal impairment (CrCl <30mL/min) and who are not receiving regularly scheduled hemodialysis: administer 1125mg as single dose, or 750mg followed by 375mg one week later.
Children
CrCl <30mL/min/1.73m2 (<18yrs): not established. Give by IV infusion over 30mins. CrCl ≥30mL/min/1.73m2 (birth–<6yrs): administer 22.5mg/kg as single dose (max 1500mg); (6–<18yrs): administer 18mg/kg as a single dose (max 1500mg).
Dalvance Contraindications
Not Applicable
Dalvance Boxed Warnings
Not Applicable
Dalvance Warnings/Precautions
Warnings/Precautions
History of glycopeptide allergy. Discontinue if hypersensitivity reactions occur; treat appropriately. Moderate or severe hepatic impairment (Child-Pugh Class B or C). Renal impairment (CrCl <30mL/min). Pregnancy. Nursing mothers.
Dalvance Pharmacokinetics
Elimination
Renal, fecal. Half-life: ~8.5 days (204 hours).
Dalvance Interactions
Not Applicable
Dalvance Adverse Reactions
Adverse Reactions
Nausea, headache, diarrhea, vomiting, rash, pruritus; in children: pyrexia; ALT elevations, infusion-related reactions, hepatic effects, C. difficile-associated diarrhea (discontinue if occurs).
Dalvance Clinical Trials
See Literature
Dalvance Note
Not Applicable
Dalvance Patient Counseling
See Literature
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