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Cleocin Pediatric Granules Generic Name & Formulations
Legal Class
Rx
General Description
Clindamycin (as palmitate HCl) 75mg/5mL; for oral soln; cherry flavor.
Pharmacological Class
Lincosamide.
See Also
How Supplied
Caps—100; Granules (100mL)—1; Inj (2mL, 4mL, 6mL vials)—25
Manufacturer
Generic Availability
YES
Cleocin Pediatric Granules Indications
Indications
Serious susceptible infections where less toxic antibiotics are inappropriate, including respiratory, skin and soft tissue, septicemia, intraabdominal, female pelvic or genital; bone and joint (inj).
Cleocin Pediatric Granules Dosage and Administration
Adult
Use capsule form.
Children
Take with full glass of water. <10kg: at least 37.5mg 3 times daily. Serious: 8–12mg/kg per day. Severe: 13–16mg/kg per day. More severe: 17–25mg/kg per day. Divide into 3–4 equal doses. Beta-hemolytic streptococcal infections: treat for at least 10 days.
Cleocin Pediatric Granules Contraindications
Not Applicable
Cleocin Pediatric Granules Boxed Warnings
Boxed Warning
C. difficile-associated diarrhea.
Cleocin Pediatric Granules Warnings/Precautions
Warnings/Precautions
Risk of C. difficile-associated diarrhea; discontinue and treat if colitis is suspected or confirmed. Reserve use for serious infections. Not for treatment of meningitis. Permanently discontinue if severe hypersensitivity reactions occur. Allergy. Asthma (75mg, 150mg caps). GI disease (esp. colitis). Atopy. Monitor blood, renal, and hepatic function in long-term use and in children. IV: Gasping syndrome (neonates, infants). Elderly. Pregnancy. Nursing mothers: consider alternative drug or monitor breast-fed infant for GI effects.
Cleocin Pediatric Granules Pharmacokinetics
See Literature
Cleocin Pediatric Granules Interactions
Interactions
May potentiate neuromuscular blocking agents; caution. May be potentiated by strong CYP3A4 inhibitors; monitor. May be antagonized by strong CYP3A4 inducers (eg, rifampicin); monitor. May antagonize erythromycin; avoid. Antiperistaltic agents may worsen colitis.
Cleocin Pediatric Granules Adverse Reactions
Adverse Reactions
Pseudomembranous colitis, C. difficile-associated diarrhea, nausea, vomiting, abdominal pain, dysguesia, rash, pruritus, angioedema, anaphylaxis, jaundice, acute kidney injury, blood dyscrasias, polyarthritis, severe skin reactions (eg, toxic epidermal necrolysis, erythema multiforme, drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome).
Cleocin Pediatric Granules Clinical Trials
See Literature
Cleocin Pediatric Granules Note
Not Applicable
Cleocin Pediatric Granules Patient Counseling
See Literature
