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Cleocin Injection Generic Name & Formulations
Legal Class
Rx
General Description
Clindamycin (as phosphate) 150mg/mL; contains benzyl alcohol.
Pharmacological Class
Lincosamide.
See Also
How Supplied
Caps—100; Granules (100mL)—1; Inj (2mL, 4mL, 6mL vials)—25
Manufacturer
Generic Availability
YES
Cleocin Injection Indications
Indications
Serious susceptible infections where less toxic antibiotics are inappropriate, including respiratory, skin and soft tissue, septicemia, intraabdominal, female pelvic or genital; bone and joint (inj).
Cleocin Injection Dosage and Administration
Adult
Serious: 0.6–1.2g daily. More severe: 1.2–2.7g/day IM or IV. Both: give in 2–4 equally divided doses; max 600mg per IM inj and 4.8g/day IV. Beta-hemolytic streptococcal infections: treat for at least 10 days.
Children
Neonates: 15–20mg/kg per day. >1 month: 20–40mg/kg per day IM or IV. Both: give in 3–4 equally divided doses. Or: serious infections: 350mg/m2 per day; more severe: 450mg/m2 per day. Beta-hemolytic streptococcal infections: treat for at least 10 days.
Cleocin Injection Contraindications
Not Applicable
Cleocin Injection Boxed Warnings
Boxed Warning
C. difficile-associated diarrhea.
Cleocin Injection Warnings/Precautions
Warnings/Precautions
Risk of C. difficile-associated diarrhea; discontinue and treat if colitis is suspected or confirmed. Reserve use for serious infections. Not for treatment of meningitis. Permanently discontinue if severe hypersensitivity reactions occur. Allergy. Asthma (75mg, 150mg caps). GI disease (esp. colitis). Atopy. Monitor blood, renal, and hepatic function in long-term use and in children. IV: Gasping syndrome (neonates, infants). Elderly. Pregnancy. Nursing mothers: consider alternative drug or monitor breast-fed infant for GI effects.
Cleocin Injection Pharmacokinetics
See Literature
Cleocin Injection Interactions
Interactions
May potentiate neuromuscular blocking agents; caution. May be potentiated by strong CYP3A4 inhibitors; monitor. May be antagonized by strong CYP3A4 inducers (eg, rifampicin); monitor. May antagonize erythromycin; avoid. Antiperistaltic agents may worsen colitis.
Cleocin Injection Adverse Reactions
Adverse Reactions
Pseudomembranous colitis, C. difficile-associated diarrhea, nausea, vomiting, abdominal pain, dysguesia, rash, pruritus, angioedema, anaphylaxis, jaundice, acute kidney injury, blood dyscrasias, polyarthritis, severe skin reactions (eg, toxic epidermal necrolysis, erythema multiforme, drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome).
Cleocin Injection Clinical Trials
See Literature
Cleocin Injection Note
Not Applicable
Cleocin Injection Patient Counseling
See Literature
