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Cleocin Generic Name & Formulations
Legal Class
Rx
General Description
Clindamycin (as HCl) 75mg+, 150mg+, 300mg; caps; +contains tartrazine.
Pharmacological Class
Lincosamide.
How Supplied
Caps—100; Granules (100mL)—1; Inj (2mL, 4mL, 6mL vials)—25
Manufacturer
Generic Availability
YES
Cleocin Indications
Indications
Serious susceptible infections where less toxic antibiotics are inappropriate, including respiratory, skin and soft tissue, septicemia, intraabdominal, female pelvic or genital; bone and joint (inj).
Cleocin Dosage and Administration
Adult
Take with full glass of water. Serious: 150–300mg every 6hrs. More severe: 300–450mg every 6hrs. Beta-hemolytic streptococcal infections: treat for at least 10 days.
Children
Take with full glass of water. Serious: 8–16mg/kg per day. More severe: 16–20mg/kg per day. Divide into 3–4 equal doses. Beta-hemolytic streptococcal infections: treat for at least 10 days.
Cleocin Contraindications
Not Applicable
Cleocin Boxed Warnings
Boxed Warning
C. difficile-associated diarrhea.
Cleocin Warnings/Precautions
Warnings/Precautions
Risk of C. difficile-associated diarrhea; discontinue and treat if colitis is suspected or confirmed. Reserve use for serious infections. Not for treatment of meningitis. Permanently discontinue if severe hypersensitivity reactions occur. Allergy. Asthma (75mg, 150mg caps). GI disease (esp. colitis). Atopy. Monitor blood, renal, and hepatic function in long-term use and in children. IV: Gasping syndrome (neonates, infants). Elderly. Pregnancy. Nursing mothers: consider alternative drug or monitor breast-fed infant for GI effects.
Cleocin Pharmacokinetics
See Literature
Cleocin Interactions
Interactions
May potentiate neuromuscular blocking agents; caution. May be potentiated by strong CYP3A4 inhibitors; monitor. May be antagonized by strong CYP3A4 inducers (eg, rifampicin); monitor. May antagonize erythromycin; avoid. Antiperistaltic agents may worsen colitis.
Cleocin Adverse Reactions
Adverse Reactions
Pseudomembranous colitis, C. difficile-associated diarrhea, nausea, vomiting, abdominal pain, dysguesia, rash, pruritus, angioedema, anaphylaxis, jaundice, acute kidney injury, blood dyscrasias, polyarthritis, severe skin reactions (eg, toxic epidermal necrolysis, erythema multiforme, drug reaction with eosinophilia and systemic symptoms, Stevens-Johnson syndrome).
Cleocin Clinical Trials
See Literature
Cleocin Note
Not Applicable
Cleocin Patient Counseling
See Literature
