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Ciprofloxacin Iv Concentrate Generic Name & Formulations
Legal Class
Rx
General Description
Ciprofloxacin 10mg/mL; soln for IV infusion after dilution.
Pharmacological Class
Quinolone.
How Supplied
Tabs—100; Oral Susp—100mL (w. graduated teaspoon); XR Tabs—50; IV premixed, IV conc—contact supplier
Manufacturer
Generic Availability
YES
Ciprofloxacin Iv Concentrate Indications
Indications
Susceptible infections, including lower respiratory tract, acute exacerbations of chronic bronchitis (AECB), skin and skin structures, bone and joint, acute sinusitis, complicated intraabdominal (w. metronidazole), UTIs, chronic bacterial prostatitis, acute uncomplicated cystitis in females. Postexposure prophylaxis and treatment of anthrax. Infectious diarrhea, typhoid fever, uncomplicated cervical and urethral gonorrhea: oral form only. Nosocomial pneumonia, empiric therapy in febrile neutropenia: IV form only. For AECB, acute sinusitis, and acute uncomplicated cystitis: reserve for those who have no alternative treatment options.
Ciprofloxacin Iv Concentrate Dosage and Administration
Adult
See full labeling. Infuse over 60 mins. Switch to oral form when appropriate. ≥18yrs: Lower respiratory tract, skin and skin structure: 400mg every 8–12hrs for 7–14 days. Nosocomial pneumonia: 400mg every 8hrs for 10–14 days. Intraabdominal (w. metronidazole): 400mg every 12hrs for 7–14 days. Bone and joint: 400mg every 8–12hrs for 4–8 weeks. Acute sinusitis: 400mg every 12hrs for 10 days. UTIs: 200–400mg every 8–12hrs for 7–14 days. Prostatitis: 400mg every 12hrs for 28 days. Febrile neutropenia: 400mg every 8hrs (+ piperacillin sodium 50mg/kg IV every 4hrs; max 24g/day) for 7–14 days. Postexposure prophylaxis of inhalational anthrax: 400mg every 12hrs for 60 days (start as soon as possible after exposure). Treatment of inhalational, GI, or oropharyngeal anthrax, or cutaneous anthrax with systemic involvement, extensive edema, or head/neck lesions: see CDC recommendations. Renal dysfunction (CrCl 5–29mL/min): 200–400mg every 18–24hrs.
Children
<18yrs: usually not recommended. See full labeling. Infuse over 60 mins. Switch to oral form when appropriate. 1–17yrs: Complicated UTIs or pyelonephritis: 6–10mg/kg (max 400mg) IV every 8hrs for 10–21 days (see full labeling). Postexposure prophylaxis of inhalational anthrax: 10mg/kg (max 400mg/dose) every 12hrs for 60 days (start as soon as possible after exposure). Treatment of inhalational, GI, cutaneous, or oropharyngeal anthrax: see CDC recommendations.
Ciprofloxacin Iv Concentrate Contraindications
Contraindications
Concomitant tizanidine.
Ciprofloxacin Iv Concentrate Boxed Warnings
Boxed Warning
Serious adverse reactions (including tendinitis and tendon rupture, peripheral neuropathy, CNS effects). Exacerbation of myasthenia gravis.
Ciprofloxacin Iv Concentrate Warnings/Precautions
Warnings/Precautions
XR not interchangeable with other forms. Increased risk of disabling and potentially irreversible adverse reactions (including tendinitis/tendon rupture [esp. in patients >60yrs, or those with kidney, heart or lung transplants], peripheral neuropathy, or CNS/psychiatric effects); discontinue immediately if signs/symptoms occur. CNS disorders (eg, cerebral arteriosclerosis, epilepsy) that increase seizure risk. History of myasthenia gravis; avoid. Renal (except XR tabs for uncomplicated UTIs) or hepatic dysfunction: reduce dose. History of QT prolongation, ventricular arrhythmias, proarrhythmic conditions (eg, bradycardia, acute myocardial ischemia), hypokalemia, or hypomagnesemia; avoid. Increased risk of aortic aneurysm and dissection (esp. in elderly); reserve use only if no alternatives in patients with history or risk of. Discontinue at 1st sign of skin rash, jaundice, any other hypersensitivity, hepatitis, or photosensitivity. Monitor blood glucose in diabetic patients; discontinue if hypoglycemia occurs. History of joint-related disorders (esp. children). Maintain adequate hydration, avoid alkaline urine to avoid crystalluria. May mask symptoms of syphilis; test for syphilis before treating gonorrhea, then follow-up after 3mos. Avoid excessive sun or UV light. Elderly. Pregnancy. Nursing mothers: may pump/discard breast milk or avoid (during and for 2 days after the last dose); monitor infant; for inhalation anthrax (post exposure): consider risk/benefit.
Ciprofloxacin Iv Concentrate Pharmacokinetics
See Literature
Ciprofloxacin Iv Concentrate Interactions
Interactions
See Contraindications. Avoid theophylline, duloxetine, zolpidem, drugs that prolong QT interval (eg, Class IA or Class III antiarrhythmics, TCAs, macrolides, antipsychotics). Oral forms: take at least 2hrs before or 6hrs after magnesium- or aluminum-containing antacids, sucralfate, metal cations, multivitamins containing zinc or iron, or didanosine (buffered forms). Increased risk of tendinitis/tendon rupture with corticosteroids. Severe hypoglycemia with oral antidiabetics (eg, glyburide, glimepiride); monitor. Increased seizure risk with concomitant NSAIDs. Potentiates caffeine/xanthine derivatives; monitor and adjust dose as needed. Potentiated by probenecid. Monitor renal function with concomitant cyclosporine. Monitor methotrexate, oral anticoagulants (eg, warfarin), phenytoin, clozapine, ropinirole, sildenafil. Reduced absorption with omeprazole (XR).
Ciprofloxacin Iv Concentrate Adverse Reactions
Adverse Reactions
Nausea, diarrhea, abnormal LFTs, vomiting, rash; tendinitis/tendon rupture, peripheral neuropathy, CNS effects, hypersensitivity reactions, hepatotoxicity, C. difficile-associated diarrhea, torsades de pointes, dysglycemia, phototoxicity, aortic aneurysm/dissection, joint-related disorders (children). IV: also inj site reactions, eosinophilia, headache, restlessness.
Ciprofloxacin Iv Concentrate Clinical Trials
See Literature
Ciprofloxacin Iv Concentrate Note
Not Applicable
Ciprofloxacin Iv Concentrate Patient Counseling
See Literature
