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Chloroquine Generic Name & Formulations
Legal Class
Rx
General Description
Chloroquine phosphate 500mg (equivalent to 300mg chloroquine base); tabs.
Pharmacological Class
Aminoquinoline.
How Supplied
Contact supplier
Manufacturer
Chloroquine Indications
Indications
Treatment of uncomplicated malaria due to susceptible strains of P. falciparum, P. malariae, P. ovale, and P. vivax. Prophylaxis of malaria in geographic areas without resistance to chloroquine.
Chloroquine Dosage and Administration
Adult
Prophylaxis: 500mg once every 7 days. Treatment: 1g once, then 500mg 6–8hrs later; then 500mg once daily for next 2 days. Low body wt: use children's dose. P. vivax and P. ovale (hypnozoite liver stage): give with concomitant 8-aminoquinoline.
Children
Prophylaxis: 8.33mg/kg (max 500mg) once every 7 days. Treatment: 16.7mg/kg (max 1g) once, then 8.33mg/kg (max 500mg) 6, 24 and 36hrs after 1st dose. P. vivax and P. ovale (hypnozoite liver stage): give with concomitant 8-aminoquinoline.
Chloroquine Contraindications
Contraindications
Retinal or visual field changes in indications other than acute malaria.
Chloroquine Boxed Warnings
Not Applicable
Chloroquine Warnings/Precautions
Warnings/Precautions
Prophylaxis: start 2 weeks before and continue for 8 weeks after trip. Monitor for cardiomyopathy esp. at high doses; discontinue if occurs. Cardiac disease. History of ventricular arrhythmias. Uncorrected hypokalemia and/or hypomagnesemia. Bradycardia. Monitor for hypoglycemia. Macular disease. Perform baseline eye exam within the first year of initiation, then annually. Avoid in psoriasis, porphyria. Discontinue if muscular weakness, ocular toxicity, or hearing defects occur. Hepatic, renal, or auditory dysfunction. Alcoholism. Seizure disorders. G6PD deficiency. Monitor CBC, reflexes in long-term use. Elderly. Children. Pregnancy (use adequate contraception in endemic areas). Nursing mothers: not recommended.
Chloroquine Pharmacokinetics
See Literature
Chloroquine Interactions
Interactions
Avoid cimetidine. Retinal toxicity with concomitant tamoxifen: not recommended. May potentiate insulin and other antidiabetic drugs: decrease doses of these. Separate ampicillin dose by 2hrs; dosing of antacids or kaolin by 4hrs. Caution with concomitant QT interval prolonging agents, arrhythmogenic, or hepatotoxic drugs. Increased risk of convulsions with concomitant mefloquine. Potentiates cyclosporine (monitor). May antagonize praziquantel.
Chloroquine Adverse Reactions
Adverse Reactions
Retinopathy, maculopathy, macular degeneration, cardiomyopathy, hearing defects, hypoglycemia, acute extrapyramidal disorders, blood dyscrasias, muscular weakness, GI upset, skin reactions, neuropsychiatric disorders.
Chloroquine Clinical Trials
See Literature
Chloroquine Note
Notes
Formerly known under the brand name Aralen.
Chloroquine Patient Counseling
See Literature
Chloroquine Generic Name & Formulations
Legal Class
Rx
General Description
Chloroquine phosphate 500mg (equivalent to 300mg chloroquine base); tabs.
Pharmacological Class
Aminoquinoline.
How Supplied
Contact supplier
Manufacturer
Chloroquine Indications
Indications
Extraintestinal amebiasis (use with intestinal amebicide).
Chloroquine Dosage and Administration
Adult
1g daily for 2 days, then 500mg daily for at least 2–3 weeks.
Children
See full labeling.
Chloroquine Contraindications
Contraindications
Retinal or visual field changes in indications other than acute malaria.
Chloroquine Boxed Warnings
Not Applicable
Chloroquine Warnings/Precautions
Warnings/Precautions
Prophylaxis: start 2 weeks before and continue for 8 weeks after trip. Monitor for cardiomyopathy esp. at high doses; discontinue if occurs. Cardiac disease. History of ventricular arrhythmias. Uncorrected hypokalemia and/or hypomagnesemia. Bradycardia. Monitor for hypoglycemia. Macular disease. Perform baseline eye exam within the first year of initiation, then annually. Avoid in psoriasis, porphyria. Discontinue if muscular weakness, ocular toxicity, or hearing defects occur. Hepatic, renal, or auditory dysfunction. Alcoholism. Seizure disorders. G6PD deficiency. Monitor CBC, reflexes in long-term use. Elderly. Children. Pregnancy (use adequate contraception in endemic areas). Nursing mothers: not recommended.
Chloroquine Pharmacokinetics
See Literature
Chloroquine Interactions
Interactions
Avoid cimetidine. Retinal toxicity with concomitant tamoxifen: not recommended. May potentiate insulin and other antidiabetic drugs: decrease doses of these. Separate ampicillin dose by 2hrs; dosing of antacids or kaolin by 4hrs. Caution with concomitant QT interval prolonging agents, arrhythmogenic, or hepatotoxic drugs. Increased risk of convulsions with concomitant mefloquine. Potentiates cyclosporine (monitor). May antagonize praziquantel.
Chloroquine Adverse Reactions
Adverse Reactions
Retinopathy, maculopathy, macular degeneration, cardiomyopathy, hearing defects, hypoglycemia, acute extrapyramidal disorders, blood dyscrasias, muscular weakness, GI upset, skin reactions, neuropsychiatric disorders.
Chloroquine Clinical Trials
See Literature
Chloroquine Note
Notes
Formerly known under the brand name Aralen.
Chloroquine Patient Counseling
See Literature
