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Chloramphenicol Inj Generic Name & Formulations
Legal Class
Rx
General Description
Chloramphenicol sodium succinate 100mg/mL; pwd for IV inj after reconstitution; sodium content 2.25 mEq/g chloramphenicol; preservative-free.
Pharmacological Class
Antibiotic.
How Supplied
Contact supplier.
Manufacturer
Chloramphenicol Inj Indications
Indications
Serious susceptible infections resistant to other antibiotics. Typhoid fever. Cystic fibrosis regimens.
Chloramphenicol Inj Dosage and Administration
Adult
Give by IV inj over ≥1-minute interval. 50mg/kg per day in 4 divided doses every 6 hours. Moderately resistant infections: may increase up to 100mg/kg per day, reduce dose as soon as possible. Typhoid fever: give for 8–10 days after patient has become afebrile. Renal or hepatic impairment: adjust or reduce dose. Switch to oral form as soon as possible.
Children
Give by IV inj over ≥1-minute interval. Premature, full-term infants <2 weeks old, or children with immature metabolic processes: 25mg/kg per day in 4 divided doses every 6 hours. Children >2 weeks old: up to 50mg/kg per day in 4 divided doses every 6 hours. Severe infections (eg, bacteremia, meningitis): up to 100mg/kg per day, reduce to 50mg/kg per day as soon as possible. Typhoid fever: give for 8–10 days after patient has become afebrile. Switch to oral form as soon as possible.
Chloramphenicol Inj Contraindications
Contraindications
Not for trivial infections or prophylaxis. Previous toxic reactions to chloramphenicol.
Chloramphenicol Inj Boxed Warnings
Not Applicable
Chloramphenicol Inj Warnings/Precautions
Warnings/Precautions
Renal or hepatic impairment. Obtain baseline CBCs then every 2 days during therapy; discontinue if blood dyscrasias, optic neuritis or peripheral neuritis develops. Avoid repeat therapy. Monitor serum levels. Premature and newborn infants. Labor & delivery. Pregnancy. Nursing mothers.
Chloramphenicol Inj Pharmacokinetics
See Literature
Chloramphenicol Inj Interactions
Interactions
Avoid other bone marrow suppressants.
Chloramphenicol Inj Adverse Reactions
Adverse Reactions
Serious/fatal blood dyscrasias, paroxysmal nocturnal hemoglobinemia, GI upset, headache, confusion, delirium, optic and peripheral neuritis, gray baby syndrome, rashes, anaphylaxis, Herxheimer reactions (w. typhoid fever).
Chloramphenicol Inj Clinical Trials
See Literature
Chloramphenicol Inj Note
Notes
Formerly known under the brand names Chlormycetin, Mychel S.
Chloramphenicol Inj Patient Counseling
See Literature
