Cefuroxime Injection Dosage & Rx Info

Cefuroxime Injection Generic Name & Formulations

Legal Class

General Description

Cefuroxime (as sodium) 750mg, 1.5g; IM or IV inj; sodium content 2.4mEq/g.

Pharmacological Class

Cephalosporin.

How Supplied

Contact supplier

Manufacturer

Various generic manufacturers

Mechanism of Action

Cefuroxime is a bactericidal agent that acts by inhibition of bacterial cell wall synthesis. Cefuroxime has activity in the presence of some beta-lactamases, both penicillinases and cephalosporinases, of Gram-negative and Gram-positive bacteria.

Cefuroxime Injection Indications

Indications

Susceptible bacterial septicemia, lower respiratory or urinary tract, skin and skin structure, meningitis, bone and joint infections, gonorrhea. Surgical prophylaxis.

Cefuroxime Injection Dosage and Administration

Adult

Use IV route for serious infections. Usual duration of therapy: 5–10 days. Uncomplicated UTIs, skin and skin structure, disseminated gonorrhea, or uncomplicated pneumonia: 750mg every 8 hours. Severe or complicated infections, bone and joint: 1.5g every 8 hours; life-threatening: 1.5g every 6 hours; meningitis: max 3g every 8 hours. Uncomplicated gonorrhea: 1.5g IM once (divide into 2 injections) with 1g oral probenecid. Prophylaxis: see full labeling. Renal dysfunction: CrCl 10–20mL/min: 750mg every 12 hours; CrCl <10mL/min: 750mg every 24 hours. Coincide a dose for end of dialysis.

Children

<3 months: not established. Give in equally divided doses. ≥3 months: usual range: 50–100mg/kg per day every 6–8 hours. Bone and joint: 150mg/kg per day every 8 hours. Meningitis: 200–240mg/kg per day IV every 6–8 hours. Renal dysfunction: reduce dose.

Cefuroxime Injection Contraindications

Not Applicable

Cefuroxime Injection Boxed Warnings

Not Applicable

Cefuroxime Injection Warnings/Precautions

Warnings/Precautions

Penicillin allergy. Renal impairment, reduce dose. Monitor prothrombin time (in patients at risk), renal function. GI disease (esp. colitis). Elderly. Pregnancy. Nursing mothers.

Cefuroxime Injection Pharmacokinetics

Elimination

Renal. Half-life: ~80 minutes.

Cefuroxime Injection Interactions

Interactions

Avoid aminoglycosides, furosemide, ethacrynic acid, other nephrotoxic drugs. May cause false (+) glucose test with Clinitest, Benedict's or Fehling's soln. Potentiated by probenecid.

Cefuroxime Injection Adverse Reactions

Adverse Reactions

Local reactions, blood dyscrasias, elevated liver enzymes; rarely: GI upset, rash (may be serious, eg, Stevens-Johnson syndrome), drug fever, anaphylaxis, interstitial nephritis, seizures, hearing loss in children treated for meningitis.

Cefuroxime Injection Clinical Trials

See Literature

Cefuroxime Injection Note

Notes

Formerly known under the brand name Zinacef.

Cefuroxime Injection Patient Counseling