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Ceftriaxone Generic Name & Formulations
Legal Class
Rx
General Description
Ceftriaxone sodium 500mg, 1g; IM or IV inj; sodium content 3.6mEq/g.
Pharmacological Class
Cephalosporin.
How Supplied
Contact supplier
Manufacturer
Ceftriaxone Indications
Indications
Susceptible bacterial infections of the lower respiratory tract, skin and skin structure, bone and joint, acute otitis media, UTIs, septicemia, pelvic inflammatory disease (PID), intraabdominal infections, meningitis, uncomplicated gonorrhea. Surgical prophylaxis.
Ceftriaxone Dosage and Administration
Adult
1–2g IM or IV once daily or in 2 equally divided doses; max 4g/day. Gonorrhea: 250mg IM once. Surgery: a single dose of 1g IV 0.5–2hrs pre-op.
Children
50–75mg/kg per day in equally divided doses every 12hrs; max 2g/day. Skin and skin structures: may give once daily or in 2 equally divided doses every 12hrs; max 2g/day. Meningitis: 100mg/kg (max 4g) for 1 dose, then 100mg/kg per day (max 4g/day) once daily or in 2 equally divided doses every 12hrs for 7–14 days. Otitis media: 50mg/kg (max 1g) IM once.
Ceftriaxone Contraindications
Contraindications
Hyperbilirubinemic or premature neonates. Concomitant calcium-containing IV solutions or products in neonates. Ceftriaxone solutions containing lidocaine for IV administration.
Ceftriaxone Boxed Warnings
Not Applicable
Ceftriaxone Warnings/Precautions
Warnings/Precautions
Penicillin or other beta-lactam allergy. Discontinue if urolithiasis, oliguria, renal or gallbladder sonographic abnormalities, signs or symptoms occur. Renal failure: monitor; decrease dose if drug accumulation occurs. Chronic hepatic disease or malnutrition (impaired Vit. K synthesis or storage): monitor prothrombin time. Both hepatic and significant renal impairment: usual max 2g/day. Ensure adequate hydration. Pregnancy (Cat.B). Nursing mothers.
Ceftriaxone Pharmacokinetics
See Literature
Ceftriaxone Interactions
Interactions
See Contraindications. Increased risk of bleeding with concomitant Vit. K antagonists. May be potentiated by probenecid. Precipitation can form with calcium-containing solutions; avoid. Monitor for methemoglobinemia with concomitant local anesthetics (eg, lidocaine). May cause false (+) Clinitest or Coomb's test.
Ceftriaxone Adverse Reactions
Adverse Reactions
Local reactions, hematologic effects (eg, eosinophilia), rash, diarrhea, elevated liver enzymes; hypersensitivity reactions, C.difficile-associated diarrhea, hemolytic anemia, pancreatitis.
Ceftriaxone Clinical Trials
See Literature
Ceftriaxone Note
Notes
Formerly known under the brand name Rocephin.
Ceftriaxone Patient Counseling
See Literature
