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Cefotaxime Generic Name & Formulations
Legal Class
Rx
General Description
Cefotaxime sodium 500mg, 1g, 2g, 10g; IM or IV inj; sodium content 2.2mEq/g.
Pharmacological Class
Cephalosporin.
How Supplied
Contact supplier
Manufacturer
Cefotaxime Indications
Indications
Susceptible bacteremia, septicemia, lower respiratory and genitourinary tracts, skin and skin structure, bone and joint, gynecologic, CNS (eg, meningitis), intraabdominal infections. Surgical prophylaxis.
Cefotaxime Dosage and Administration
Adult
Uncomplicated infections: 1g every 12 hours. Moderate-to-severe infections: 1–2g every 8 hours. Infections commonly needing a higher dosage (eg, septicemia): 2g IV every 6–8 hours. Life-threatening infections: 2g IV every 4 hours. Gonococcal urethritis or cervicitis: 0.5g IM once. Rectal gonorrhea: 0.5g (women) or 1g (men) IM once. All: max 12g/day. Post-op prophylaxis: give 1g as single dose 30–90mins before surgery. Cesarean section: 1st dose: 1g IV as soon as umbilical cord clamped; 2nd and 3rd dose: 1g at 6 and 12 hours after 1st dose. CrCl <20mL/min/1.73m2: consider reducing dose by one-half.
Children
Neonates up to 1 week of age: 50mg/kg IV every 12 hours. 1–4 weeks of age: 50mg/kg IV every 8 hours. Over 1 month of age (<50kg): 50–180mg/kg in 4–6 equally divided doses. ≥50kg: as adult; max 12g/day.
Cefotaxime Contraindications
Not Applicable
Cefotaxime Boxed Warnings
Not Applicable
Cefotaxime Warnings/Precautions
Warnings/Precautions
Penicillin or other allergy. Monitor blood counts in treatments >10 days. Renal impairment, reduce dose. GI disease (esp. colitis). Avoid extravasation. Pregnancy (Cat.B). Nursing mothers.
Cefotaxime Pharmacokinetics
See Literature
Cefotaxime Interactions
Interactions
Increased nephrotoxicity with concomitant aminoglycosides, NSAIDs, furosemide. Potentiated by probenecid; avoid cefotaxime doses >6g/day. May cause false (+) Fehling's or Benedict's soln, Clinitest, or Coomb's test.
Cefotaxime Adverse Reactions
Adverse Reactions
Inj site reactions, colitis, diarrhea, nausea, vomiting, hypersensitivity (discontinue if occurs); blood dyscrasias, elevated liver enzymes (rare).
Cefotaxime Clinical Trials
See Literature
Cefotaxime Note
Notes
Formerly known under the brand name Claforan.
Cefotaxime Patient Counseling
See Literature
