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Bat Generic Name & Formulations
Legal Class
Rx
General Description
Botulism antitoxin heptavalent A, B, C, D, E, F, G (Equine); soln for IV infusion after dilution; preservative-free; contains maltose, polysorbate 80.
Pharmacological Class
Immune globulin.
How Supplied
Single-dose vial (20mL, 50mL)—1
Manufacturer
Generic Availability
NO
Bat Indications
Indications
Symptomatic botulism following exposure to botulinum neurotoxin serotypes A, B, C, D, E, F, or G.
Bat Dosage and Administration
Adult
See full labeling. Administer as slow IV infusion. ≥17yrs: give 1 vial at a rate of 0.5mL/min for first 30mins; double the rate every 30mins if tolerated; max rate 2mL/min. Risk for hypersensitivity reaction: start at lowest rate possible (<0.01mL/min); monitor.
Children
See full labeling. Calculate dose by body wt based on Salisbury Rule. Administer as slow IV infusion. <1yr: give 10% of adult dose at a rate of 0.01mL/kg/min for first 30mins; increase in 0.01mL/kg/min every 30mins if tolerated; max rate 0.03mL/kg/min. 1–<17yrs: give 20–100% of adult dose at a rate of 0.01mL/kg/min for first 30mins; increase in 0.01mL/kg/min every 30mins if tolerated; max rate 0.03mL/kg/min (not to exceed adult rate). Risk for hypersensitivity reaction: start at lowest rate possible (<0.01mL/min); monitor.
Bat Contraindications
Not Applicable
Bat Boxed Warnings
Not Applicable
Bat Warnings/Precautions
Warnings/Precautions
Increased risk for severe hypersensitivity reactions if previous therapy with equine-derived antivenom/antitoxin, history of hypersensitivity to horses, asthma, or hay fever. Have appropriate equipment, medication (including epinephrine), and trained personnel readily available. Monitor for acute allergic reaction during and after infusion; discontinue immediately if hypersensitivity reactions occur. Monitor for delayed allergic reactions (serum sickness), vital signs during infusion. Reduce infusion rate if infusion-related reactions occur; discontinue if symptoms worsen. Contains equine plasma; risk of viral transmission. Elderly. Pregnancy. Nursing mothers.
Bat Pharmacokinetics
See Literature
Bat Interactions
Interactions
Maltose content: may interfere with certain blood glucose monitoring systems and can result in falsely elevated glucose readings; use test systems that are glucose-specific.
Bat Adverse Reactions
Adverse Reactions
Headache, nausea, pruritus, urticaria, pyrexia, rash, chills, edema; hemodynamic instability (eg, tachycardia, bradycardia, asystole), hypersensitivity reactions, serum sickness.
Bat Clinical Trials
See Literature
Bat Note
Not Applicable
Bat Patient Counseling
See Literature
