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Azactam Generic Name & Formulations
Legal Class
Rx
General Description
Aztreonam 1g, 2g; for IM or IV inj after reconstitution; sodium-free.
Pharmacological Class
Monobactam.
How Supplied
Single-dose vials (15mL)—10; GALAXY containers (50mL)—24
Manufacturer
Azactam Indications
Indications
Susceptible bacterial infections, including septicemia, lower respiratory tract, complicated or uncomplicated urinary tract, skin and skin structure, gynecologic, intraabdominal. Surgical adjunct.
Azactam Dosage and Administration
Adult
UTI: 500mg–1g every 8–12hrs. Other systemic infections: moderately severe: 1–2g every 8–12hrs; severe: 2g every 6–8hrs. All: max 8g/day. Max 1g/dose by IM. Renal impairment (CrCl 10–30mL/min): ½ of dose after loading dose; CrCl <10mL/min: see full labeling.
Children
<9mos: not established. Not for septicemia or certain skin and skin structure infections; see full labeling. 9mos–16yrs (normal renal function only): urinary tract, lower respiratory tract, intraabdominal, gynecologic infections: mild-to-moderate: 30mg/kg IV every 8hrs; moderate-to-severe: 30mg/kg IV every 6–8hrs; max 120mg/kg/day. May need higher dose in patients with cystic fibrosis.
Azactam Contraindications
Not Applicable
Azactam Boxed Warnings
Not Applicable
Azactam Warnings/Precautions
Warnings/Precautions
Penicillin, cephalosporin, carbapenem, or other allergy. Renal or hepatic impairment; monitor during therapy. Elderly. Pregnancy (Cat.B). Nursing mothers; consider temporary formula feedings.
Azactam Pharmacokinetics
See Literature
Azactam Interactions
Interactions
May potentiate nephrotoxicity of concomitant aminoglycosides (esp. at high doses or prolonged use); monitor renal function. Avoid concomitant β-lactamase-inducing drugs (eg, cefoxitin, imipenem).
Azactam Adverse Reactions
Adverse Reactions
Local reactions (eg, phlebitis, discomfort), GI upset, rash, anaphylaxis, blood dyscrasias, elevated liver enzymes or serum creatinine; C. difficile-associated diarrhea, superinfection; rare: toxic epidermal necrolysis.
Azactam Clinical Trials
See Literature
Azactam Note
Not Applicable
Azactam Patient Counseling
See Literature
