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Augmentin Suspension Generic Name & Formulations
Legal Class
Rx
General Description
Amoxicillin, clavulanic acid (as potassium) 125mg/31.25mg banana flavor; 250mg/62.5mg orange flavor; per 5mL.
Pharmacological Class
Broad-spectrum penicillin + β-lactamase inhibitor.
See Also
How Supplied
Ext-rel tabs—contact supplier; Tabs 875mg—20; Susp 125mg/5mL, 250mg/5mL—75mL, 100mL, 150mL; Chew tabs—contact supplier; Susp ES-600 600mg/5mL—50mL, 75mL, 100mL, 125mL, 150mL, 200mL
Manufacturer
Augmentin Suspension Indications
Indications
Susceptible infections including sinusitis due to β-lactamase producing organisms, otitis media, lower respiratory or skin and skin structure infections, UTIs.
Augmentin Suspension Dosage and Administration
Adult
Take with meals. Base dose on amoxicillin component. Due to clavulanic acid component: two 250mg tabs are not equivalent to one 500mg tab. May use 125mg/5mL or 250mg/5mL susp in place of 500mg tab; or 200mg/5mL or 400mg/5mL susp in place of 875mg tab. Severe infections or respiratory tract infections: 875mg every 12 hrs or 500mg every 8 hrs. Others: 500mg every 12 hrs or 250mg every 8 hrs. Renal impairment: CrCl<30mL/min: do not use 875mg tabs. CrCl: 10–30mL/min: 250–500mg every 12 hrs. CrCl<10mL/min: 250mg–500mg every 24 hrs; hemodialysis: give additional doses during and after dialysis.
Children
Take with meals. Base dose on amoxicillin component. <12 weeks: 30mg/kg/day in 2 divided doses every 12 hrs (use 125mg/5mL). ≥12 weeks: Twice-daily regimen: use 200mg/5mL or 400mg/5mL. Three times daily regimen: use 125mg/5mL or 250mg/5mL. Less severe infections: 25mg/kg/day in 2 divided doses every 12 hrs or 20mg/kg/day in 3 divided doses every 8 hrs. Others: 45mg/kg/day in 2 divided doses every 12 hrs or 40mg/kg/day in 3 divided doses every 8 hrs. ≥40kg: see Adult dose.
Augmentin Suspension Contraindications
Contraindications
History of amoxicillin/clavulanic acid-associated cholestatic jaundice/hepatic dysfunction. Ext-rel: Severe renal impairment (CrCl <30mL/min) or hemodialysis.
Augmentin Suspension Boxed Warnings
Not Applicable
Augmentin Suspension Warnings/Precautions
Warnings/Precautions
Cephalosporin, imipenem, or other allergy: not recommended. Monitor blood, renal, and hepatic function in long-term use. Monitor closely if skin rash develops; discontinue if lesions progress. Hepatic dysfunction. Mononucleosis. Elderly (consider monitoring renal function). Labor & delivery. Pregnancy (Cat.B). Nursing mothers.
Augmentin Suspension Pharmacokinetics
See Literature
Augmentin Suspension Interactions
Interactions
May cause false (+) glucose test with Clinitest, Benedict's or Fehling's soln. Probenecid potentiates amoxicillin. May potentiate oral anticoagulants (monitor). May antagonize oral contraceptives.
Augmentin Suspension Adverse Reactions
Adverse Reactions
Diarrhea, nausea, abdominal pain, rash, urticaria, vomiting, vaginitis; anaphylaxis, severe cutaneous adverse reactions (eg, SJS, TEN, DRESS, AGEP).
Augmentin Suspension Clinical Trials
See Literature
Augmentin Suspension Note
Not Applicable
Augmentin Suspension Patient Counseling
See Literature
