Anthrasil

Have appropriate equipment, medication (including epinephrine), and trained personnel readily available. Monitor and discontinue immediately if severe hypersensitivity reactions occur. Increased thrombosis risk in cardiovascular disorders, advanced age, impaired cardiac output, hypercoagulable disorders, prolonged immobilization, history of arterial or venous thrombosis, estrogen use, indwelling central vascular catheter, and/or known or suspected hyperviscosity; infuse at minimum rate practicable; monitor. Ensure adequate hydration. Consider baseline assessment of blood viscosity in those at risk of hyperviscosity, including cryoglobulins, chylomicronemia, markedly high triglycerides, or monoclonal gammopathies. Pre-existing renal insufficiency or risk of (eg, diabetes mellitus, age >65yrs, volume depletion, paraproteinemia, sepsis, taking nephrotoxic drugs); infuse at minimum rate practicable; monitor. Assess renal function, urine output, BUN, serum creatinine, prior to initial infusion and periodically thereafter; consider discontinuing if renal function deteriorates. Do not exceed recommended infusion rate. Monitor for infusion reactions; slow infusion rate or interrupt if occur. High doses (>2g/kg given as single dose or over several days), non-O blood group, or underlying inflammatory state; monitor for hemolysis. Consider measuring hemoglobin/hematocrit prior to infusion, within ~36–96hrs, and again ~7–10 days post-infusion. Perform neurological exam if signs/symptoms of aseptic meningitis syndrome develop (including CSF studies). Monitor for pulmonary adverse reactions; if transfusion-related acute lung injury (TRALI) suspected, perform appropriate tests. Contains human plasma; monitor for possible viral disease and variant Creutzfeldt-Jakob disease transmission. Pregnancy. Nursing mothers.