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Anthim Generic Name & Formulations
Legal Class
Rx
General Description
Obiltoxaximab 100mg/mL; soln for IV infusion after dilution; preservative-free; contains sorbitol.
Pharmacological Class
Monoclonal antibody.
How Supplied
Single-dose vial (6mL)—1
Manufacturer
Generic Availability
NO
Anthim Indications
Indications
Treatment of inhalational anthrax in combination with appropriate antibacterial drugs. Prophylaxis of inhalational anthrax when alternative therapies are not available or are not appropriate.
Limitations of Use
Only use for prophylaxis when its benefit of anthrax prevention outweighs risk of hypersensitivity and anaphylaxis. Has no direct antibacterial activity. Does not cross the blood-brain barrier. Does not prevent or treat meningitis. Pediatrics: safety and pharmacokinetics were not studied.
Anthim Dosage and Administration
Adult
See full labeling. Premedicate with diphenhydramine prior to infusion. Give as IV infusion over 90mins. >40kg: 16mg/kg.
Children
See full labeling. Premedicate with diphenhydramine prior to infusion. Give as IV infusion over 90mins. ≤15kg: 32mg/kg; >15–40kg: 24mg/kg; >40kg: use adult dose.
Anthim Contraindications
Not Applicable
Anthim Boxed Warnings
Boxed Warning
Hypersensitivity. Anaphylaxis.
Anthim Warnings/Precautions
Warnings/Precautions
Have trained personnel and medical equipment readily available. Monitor infusion during and after administration. Discontinue immediately and treat if anaphylaxis or hypersensitivity reactions occur. Pregnancy. Nursing mothers.
Anthim Pharmacokinetics
See Literature
Anthim Interactions
Not Applicable
Anthim Adverse Reactions
Adverse Reactions
Headache, pruritus, infections of the upper respiratory tract, cough, vessel puncture site bruise, infusion site swelling, nasal congestion, infusion
site pain, urticaria, pain in extremity.
Anthim Clinical Trials
See Literature
Anthim Note
Not Applicable
Anthim Patient Counseling
See Literature
