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Ancobon Generic Name & Formulations
Legal Class
Rx
General Description
Flucytosine 250mg, 500mg; caps.
Pharmacological Class
Antifungal.
How Supplied
Caps—100
Manufacturer
Generic Availability
YES
Ancobon Indications
Indications
In combination with amphotericin B: Candida infections in septicemia, endocarditis, UTIs and pulmonary infections; cryptococcus infections in meningitis, pulmonary, septicemia, and UTIs.
Ancobon Dosage and Administration
Adults and Children
Usually 50–150mg/kg per day given in divided doses every 6hrs. To minimize GI upset, give a few capsules at a time over 15mins. Renal impairment: give initial dose at lower range.
Ancobon Contraindications
Contraindications
Known complete dihydropyrimidine dehydrogenase (DPD) enzyme deficiency.
Ancobon Boxed Warnings
Boxed Warning
Use extreme caution in patients with impaired renal function.
Ancobon Warnings/Precautions
Warnings/Precautions
Increased risk of severe drug toxicity in patients with DPD deficiency (see Contraindications). Consider discontinuing treatment if drug toxicity is suspected. Renal or hepatic impairment. Monitor electrolytes, blood count, renal and hepatic function before and during therapy. Bone marrow depression (eg, hematologic disease, history or currently treated with radiation or bone marrow depressants). Pregnancy. Nursing mothers: not recommended.
Ancobon Pharmacokinetics
See Literature
Ancobon Interactions
Interactions
Antagonized by cytosine arabinoside. May be potentiated by drugs that impair glomerular filtration.
Ancobon Adverse Reactions
Adverse Reactions
Cardiac events, chest pain, dyspnea, GI upset, abdominal pain, hepatic dysfunction, elevated creatinine and BUN, blood dyscrasias, ataxia, headache, confusion, fatigue, hypoglycemia, hypokalemia, rash, allergic reactions, others.
Ancobon Clinical Trials
See Literature
Ancobon Note
Not Applicable
Ancobon Patient Counseling
See Literature
