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Ampicillin Sodium Injection Generic Name & Formulations
Legal Class
Rx
General Description
Ampicillin sodium 125mg, 250mg, 500mg, 1g, 2g, 10g; per vial; pwd for IV or IM inj after reconstitution and dilution.
Pharmacological Class
Broad-spectrum penicillin.
See Also
How Supplied
Contact supplier.
Manufacturer
Mechanism of Action
Ampicillin is similar to penicillin in its bactericidal action against susceptible bacteria during the stage of active multiplication. It acts through the inhibition of cell wall biosynthesis that leads to the death of the bacteria.
Ampicillin Sodium Injection Indications
Indications
Ampicillin-sensitive infections.
Ampicillin Sodium Injection Dosage and Administration
Adults and Children
Give IV inj slowly over at least 10–15 minutes; rapid IV administration may result in convulsive seizures. Respiratory tract and soft tissue infections: <40kg: 25–50mg/kg per day in equally divided doses every 6–8 hours. ≥40kg: 250–500mg every 6 hours. GI or GU tract infections (including N. gonorrhoeae in women): <40kg: 50mg/kg per day in equally divided doses every 6–8 hours. ≥40kg: 500mg every 6 hours. Urethritis in males due to N. gonorrhoeae: two doses of 500mg each at interval of 8–12 hours. Meningitis: Initiate with IV drip, then continue IM. 150–200mg/kg per day in equally divided doses every 3–4 hours. Septicimia: Initiate IV for at least 3 days, then continue IM every 3–4 hours. 150–200mg/kg per day; treat for at least 10 days if caused by Group A β-hemolytic streptococci.
Ampicillin Sodium Injection Contraindications
Not Applicable
Ampicillin Sodium Injection Boxed Warnings
Not Applicable
Ampicillin Sodium Injection Warnings/Precautions
Warnings/Precautions
Cephalosporin, imipenem, other allergy or mononucleosis: not recommended. Monitor blood, renal, and liver function in long-term use. Pregnancy (Cat.B). Nursing mothers.
Ampicillin Sodium Injection Pharmacokinetics
Elimination
Renal.
Ampicillin Sodium Injection Interactions
Interactions
May cause false (+) glucose test with Clinitest, Benedict's or Fehling's soln. Potentiated by probenecid. May increase risk of rash with allopurinol.
Ampicillin Sodium Injection Adverse Reactions
Adverse Reactions
Anaphylaxis, urticaria, GI upset, blood dyscrasias.
Ampicillin Sodium Injection Clinical Trials
See Literature
Ampicillin Sodium Injection Note
Notes
Formerly known under the brand names Principen, Totacillin, Pfizerpen-A, Penbritin, Omnipen, Amcill (caps, susp); Polycillin-N, Totacillin-N, Penbritin-S, Omnipen-N (inj).
Ampicillin Sodium Injection Patient Counseling
See Literature
