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Amoxicillin/clavulanic Acid Ext-rel Generic Name & Formulations
Legal Class
Rx
General Description
Amoxicillin 1000mg, clavulanic acid (as potassium) 62.5mg; scored ext-rel tabs.
Pharmacological Class
Broad-spectrum penicillin + β-lactamase inhibitor.
See Also
How Supplied
Ext-rel tabs—contact supplier; Tabs 875mg—20; Susp 125mg/5mL, 250mg/5mL—75mL, 100mL, 150mL; Chew tabs—contact supplier; Susp ES-600 600mg/5mL—50mL, 75mL, 100mL, 125mL, 150mL, 200mL
Manufacturer
Amoxicillin/clavulanic Acid Ext-rel Indications
Indications
Susceptible infections including community-acquired pneumonia and acute bacterial sinusitis (see full labeling).
Amoxicillin/clavulanic Acid Ext-rel Dosage and Administration
Adult
Take with meals. May split scored tabs; do not reduce dose. Two amoxicillin/clavulanic acid 500mg tabs are not equivalent to one ext-rel tab. ≥16yrs: 2 tabs every 12 hrs. Sinusitis: treat for 10 days. CAP: treat for 7–10 days.
Children
<16yrs: not recommended.
Amoxicillin/clavulanic Acid Ext-rel Contraindications
Contraindications
History of amoxicillin/clavulanic acid-associated cholestatic jaundice/hepatic dysfunction. Ext-rel: Severe renal impairment (CrCl <30mL/min) or hemodialysis.
Amoxicillin/clavulanic Acid Ext-rel Boxed Warnings
Not Applicable
Amoxicillin/clavulanic Acid Ext-rel Warnings/Precautions
Warnings/Precautions
Cephalosporin, imipenem, or other allergy: not recommended. Monitor blood, renal, and hepatic function in long-term use. Monitor closely if skin rash develops; discontinue if lesions progress. Hepatic dysfunction. Mononucleosis. Elderly (consider monitoring renal function). Labor & delivery. Pregnancy (Cat.B). Nursing mothers.
Amoxicillin/clavulanic Acid Ext-rel Pharmacokinetics
See Literature
Amoxicillin/clavulanic Acid Ext-rel Interactions
Interactions
May cause false (+) glucose test with Clinitest, Benedict's or Fehling's soln. Probenecid potentiates amoxicillin. May potentiate oral anticoagulants (monitor). May antagonize oral contraceptives.
Amoxicillin/clavulanic Acid Ext-rel Adverse Reactions
Adverse Reactions
Diarrhea, nausea, abdominal pain, rash, urticaria, vomiting, vaginitis; anaphylaxis, severe cutaneous adverse reactions (eg, SJS, TEN, DRESS, AGEP).
Amoxicillin/clavulanic Acid Ext-rel Clinical Trials
See Literature
Amoxicillin/clavulanic Acid Ext-rel Note
Not Applicable
Amoxicillin/clavulanic Acid Ext-rel Patient Counseling
See Literature
