Amoxicillin Dosage & Rx Info | Uses, Side Effects

Amoxicillin Generic Name & Formulations

Legal Class

General Description

Amoxicillin (as trihydrate) 250mg, 500mg; caps.

Pharmacological Class

Broad-spectrum penicillin.

How Supplied

Contact supplier

Manufacturer

Various generic manufacturers

Amoxicillin Indications

Indications

Susceptible infections including ear/nose/throat (ENT), genitourinary tract, skin and skin structures, lower respiratory, acute uncomplicated gonorrhea.

Amoxicillin Dosage and Administration

Adult

ENT, genitourinary, or skin: 250mg every 8hrs. Severe, less susceptible, or lower respiratory infections: 500mg every 8hrs. Gonorrhea: 3g once. Renal impairment: glomerular filtration rate (GFR) 10–30mL/min: 250mg or 500mg every 12hrs; GFR <10mL/min or hemodialysis: 250mg or 500mg every 24hrs (give additional dose during and at end of dialysis).

Children

≥40kg: as adult. ≤3 months: max 30mg/kg per day in 2 divided doses every 12hrs. >3 months (<40kg): ENT, genitourinary, skin: 20mg/kg per day in 3 divided doses every 8hrs. Severe, less susceptible, or lower respiratory infections: 40mg/kg per day in 3 divided doses every 8hrs. Gonorrhea: <2yrs: not recommended; prepubertal: amoxicillin 50mg/kg + probenecid 25mg/kg as a single dose.

Amoxicillin Contraindications

Not Applicable

Amoxicillin Boxed Warnings

Not Applicable

Amoxicillin Warnings/Precautions

Warnings/Precautions

Cephalosporin, imipenem or other allergy: not recommended. Monitor blood, renal, and hepatic function in long-term use. Monitor closely if skin rash develops; discontinue if lesions progress. Mononucleosis. Labor & delivery. Pregnancy (Cat.B). Nursing mothers.

Amoxicillin Pharmacokinetics

Metabolism

Hepatic.

Elimination

Renal. Half-life: 61.3 minutes.

Amoxicillin Interactions

Interactions

May cause false (+) glucose test with Clinitest, Benedict's or Fehling's soln. Serum levels increased by probenecid.

Amoxicillin Adverse Reactions

Adverse Reactions

Diarrhea, rash, vomiting, nausea; anaphylaxis, severe cutaneous adverse reactions (eg, SJS, TEN, DRESS, AGEP), hyperactivity, blood dyscrasias.

Amoxicillin Clinical Trials

See Literature

Amoxicillin Note

Notes

Formerly known under the brand names Amoxil, Trimox, Ultimox, Wymox (caps, susp), Polymox (susp).

Amoxicillin Patient Counseling